Slc7a3 solute carrier family 7 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a3provided by RGD
Official Full Name: solute carrier family 7 member 3provided by RGD
Primary source: RGD:68342
See related: EnsemblRapid:ENSRNOG00000004133 AllianceGenome:RGD:68342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cat3; Atrc3; cat-3; Slc7a2
Summary: Enables L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Involved in carboxylic acid transport and regulation of TOR signaling. Predicted to be active in plasma membrane. Orthologous to human SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 33.2), Spleen (RPKM 8.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (70250089..70256610, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (66210071..66216482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (70972767..70979466, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The influence of NMDA receptor activation on mammalian target of rapamycin (mTOR) activity and neuronal process extension is mediated by CAT3.
Title: The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lysine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-lysine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-lysine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-ornithine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ornithine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-ornithine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables basic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables basic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-arginine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-lysine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-lysine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-lysine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-ornithine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-ornithine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within basic amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in lysine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ornithine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cationic amino acid transporter 3

Names: amino acid transporter, cationic 3; cationic amino acid transporter y+; solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431569.1 → NP_001418498.1 cationic amino acid transporter 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6IQ96
NM_017217.2 → NP_058913.2 cationic amino acid transporter 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6IQ96

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

70250089..70256610 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257059.5 → XP_006257121.1 cationic amino acid transporter 3 isoform X1

Related

ENSRNOP00000068115.3, ENSRNOT00000076336.3

Conserved Domains (1) summary

TIGR00906
Location:4 → 591

2A0303; cationic amino acid transport permease
XM_063279852.1 → XP_063135922.1 cationic amino acid transporter 3 isoform X1