Coro1b coronin 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coro1bprovided by RGD
Official Full Name: coronin 1Bprovided by RGD
Primary source: RGD:2382
See related: EnsemblRapid:ENSRNOG00000021828 AllianceGenome:RGD:2382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Arp2/3 complex binding activity and cytoskeletal protein binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of lamellipodium morphogenesis; and negative regulation of smooth muscle cell chemotaxis. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 969.2), Thymus (RPKM 664.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210872437..210877876)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201442977..201448416)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219397827..219403253)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that phosphorylation of Coro1B and the subsequent reduced interaction with ARP2/3 complex participate in PDGF-induced VSMC migration, an important step in vascular lesion formation.
Title: Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.
Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration.
Title: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
F-actin binding is absolutely required for coronin 1B to exert its effects on whole-cell motility and lamellipodial dynamics.
Title: F-actin binding is essential for coronin 1B function in vivo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128227 (e-PCR)
- UniSTS:211535

RH142280 (e-PCR)
- UniSTS:231527

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IEA Inferred from Electronic Annotation more info
enables Arp2/3 complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament branching	IEA Inferred from Electronic Annotation more info
involved_in actin filament branching	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to platelet-derived growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell leading edge	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IC Inferred by Curator more info	PubMed
involved_in ruffle organization	IEA Inferred from Electronic Annotation more info
involved_in ruffle organization	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-1B

Names: coronin, actin-binding protein, 1B; coronin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019222.2 → NP_062095.2 coronin-1B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O89046

UniProtKB/TrEMBL

A6HYU3, G3V940

Related

ENSRNOP00000081471.2, ENSRNOT00000094725.2

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 480

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

210872437..210877876

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230774.5 → XP_006230836.1 coronin-1B isoform X1

See identical proteins and their annotated locations for XP_006230836.1

UniProtKB/Swiss-Prot

O89046

UniProtKB/TrEMBL

A6HYU3, G3V940

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 480

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006230773.4 → XP_006230835.1 coronin-1B isoform X1

See identical proteins and their annotated locations for XP_006230835.1

UniProtKB/Swiss-Prot

O89046

UniProtKB/TrEMBL

A6HYU3, G3V940

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 480

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...