Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppwd1provided by RGD
Official Full Name: peptidylprolyl isomerase domain and WD repeat containing 1provided by RGD
Primary source: RGD:1310204
See related: EnsemblRapid:ENSRNOG00000012505 AllianceGenome:RGD:1310204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310204
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in nuclear body. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 56.7), Thymus (RPKM 56.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (37069744..37094252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (35337301..35360661, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (34288853..34313094, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidylprolyl isomerase domain and WD repeat-containing protein 1

NP_001099876.1

EC 5.2.1.8

XP_006231949.1

EC 5.2.1.8

XP_038957858.1

EC 5.2.1.8

XP_038957859.1

EC 5.2.1.8

XP_063137576.1

EC 5.2.1.8

XP_063137577.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106406.1 → NP_001099876.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_001099876.1

Status: PROVISIONAL

Source sequence(s)

CH473955

UniProtKB/TrEMBL

A0A8I6G302, A6I5F6, D3ZVP6

Related

ENSRNOP00000016863.5, ENSRNOT00000016863.7

Conserved Domains (4) summary

COG2319
Location:89 → 311

WD40; WD40 repeat [General function prediction only]

cd01927
Location:495 → 643

cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...

sd00039
Location:136 → 177

7WD40; WD40 repeat [structural motif]

cl02567
Location:89 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

37069744..37094252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281506.1 → XP_063137576.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X4
XM_006231887.5 → XP_006231949.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6G302

Conserved Domains (3) summary

cd01927
Location:414 → 562

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...

sd00039
Location:55 → 96

7WD40; WD40 repeat [structural motif]

cl29593
Location:8 → 237

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063281507.1 → XP_063137577.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X5
XM_039101930.2 → XP_038957858.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X2

Conserved Domains (2) summary

sd00039
Location:136 → 177

7WD40; WD40 repeat [structural motif]

cl29593
Location:89 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039101931.2 → XP_038957859.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

Conserved Domains (2) summary

sd00039
Location:136 → 177

7WD40; WD40 repeat [structural motif]

cl29593
Location:89 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...