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Ssr4 signal sequence receptor subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29435, updated on 17-Aug-2024

Summary

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Official Symbol
Ssr4provided by RGD
Official Full Name
signal sequence receptor subunit 4provided by RGD
Primary source
RGD:62034
See related
EnsemblRapid:ENSRNOG00000053172 AllianceGenome:RGD:62034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 529.1), Spleen (RPKM 460.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq37
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156675658..156679545)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151524191..151528218)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156995763..156999702, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SRSF protein kinase 3 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene PDZ domain containing 4 Neighboring gene L1 cell adhesion molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A tetrameric complex of membrane proteins in the endoplasmic reticulum. Hartmann E, et al. Eur J Biochem, 1993 Jun 1. PMID 7916687
  2. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of Sec61 translocon complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translocon-associated protein subunit delta
Names
SSR-delta
TRAP-delta
signal sequence receptor 4
signal sequence receptor subunit delta
signal sequence receptor, delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017199.1 → NP_058895.1  translocon-associated protein subunit delta precursor

    See identical proteins and their annotated locations for NP_058895.1

    Status: PROVISIONAL

    Source sequence(s)
    Z19087
    UniProtKB/Swiss-Prot
    Q07984
    UniProtKB/TrEMBL
    A6KRU9, A6KRV0
    Related
    ENSRNOP00000070206.3, ENSRNOT00000083557.3
    Conserved Domains (1) summary
    pfam05404
    Location:22 → 172
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156675658..156679545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279850.1 → XP_063135920.1  translocon-associated protein subunit delta isoform X2

  2. XM_063279851.1 → XP_063135921.1  translocon-associated protein subunit delta isoform X3

  3. XM_006229571.5 → XP_006229633.1  translocon-associated protein subunit delta isoform X1

    UniProtKB/TrEMBL
    A0A8L2R221, A6KRU9
    Conserved Domains (1) summary
    pfam05404
    Location:22 → 171
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07984.1 GenPept UniProtKB/Swiss-Prot:Q07984

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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