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Cuta cutA divalent cation tolerance homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 294288, updated on 2-Nov-2024

Summary

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Official Symbol
Cutaprovided by RGD
Official Full Name
cutA divalent cation tolerance homologprovided by RGD
Primary source
RGD:1303306
See related
EnsemblRapid:ENSRNOG00000000481 AllianceGenome:RGD:1303306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CutA1
Summary
Predicted to enable copper ion binding activity and enzyme binding activity. Involved in protein localization. Predicted to be located in membrane and mitochondrion. Orthologous to human CUTA (cutA divalent cation tolerance homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 94.3), Heart (RPKM 93.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cuta in Genome Data Viewer
Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5024816..5026446, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5022956..5024580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5532024..5533640, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene zinc finger and BTB domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase. Liang D, et al. J Biol Chem, 2009 Feb 20. PMID 19049969
  2. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. Perrier AL, et al. J Biol Chem, 2000 Nov 3. PMID 10954708
  3. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. Navaratnam DS, et al. J Neurochem, 2000 May. PMID 10800960
  4. The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction. Arnesano F, et al. J Biol Chem, 2003 Nov 14. PMID 12949080
  5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase.
    Title: Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase.
  2. comparative x-ray crystallography analysis suggests CutA1 proteins have a role in signal transduction through allosteric communications between subunits.
    Title: The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to metal ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein CutA
Names
brain acetylcholinesterase putative membrane anchor
divalent cation tolerant protein CUTA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164706.1 → NP_001158178.1  protein CutA isoform 2

    See identical proteins and their annotated locations for NP_001158178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
    Source sequence(s)
    BX883042, CB586341
    UniProtKB/Swiss-Prot
    Q6MGD0
    UniProtKB/TrEMBL
    A0A0G2JT00, A6JJJ6
    Conserved Domains (1) summary
    pfam03091
    Location:46 → 141
    CutA1; CutA1 divalent ion tolerance protein

  2. NM_001164707.1 → NP_001158179.1  protein CutA isoform 2

    See identical proteins and their annotated locations for NP_001158179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
    Source sequence(s)
    BP501235, BX883042, DV717217
    UniProtKB/Swiss-Prot
    Q6MGD0
    UniProtKB/TrEMBL
    A0A0G2JT00, A6JJJ6
    Conserved Domains (1) summary
    pfam03091
    Location:46 → 141
    CutA1; CutA1 divalent ion tolerance protein

  3. NM_212494.2 → NP_997659.2  protein CutA isoform 1 precursor

    See identical proteins and their annotated locations for NP_997659.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX883042
    UniProtKB/Swiss-Prot
    Q6MGD0
    UniProtKB/TrEMBL
    A6JJJ5, G3V616
    Related
    ENSRNOP00000000568.2, ENSRNOT00000000568.8
    Conserved Domains (1) summary
    pfam03091
    Location:69 → 164
    CutA1; CutA1 divalent ion tolerance protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    5024816..5026446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256120.5 → XP_006256182.1  protein CutA isoform X1

    See identical proteins and their annotated locations for XP_006256182.1

    UniProtKB/Swiss-Prot
    Q6MGD0
    UniProtKB/TrEMBL
    A6JJJ5, G3V616
    Conserved Domains (1) summary
    pfam03091
    Location:69 → 164
    CutA1; CutA1 divalent ion tolerance protein

RNA

  1. XR_005497189.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MGD0.2 GenPept UniProtKB/Swiss-Prot:Q6MGD0

Gene LinkOut

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