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Slc39a7 solute carrier family 39 member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294281, updated on 2-Nov-2024

Summary

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Official Symbol
Slc39a7provided by RGD
Official Full Name
solute carrier family 39 member 7provided by RGD
Primary source
RGD:1593280
See related
EnsemblRapid:ENSRNOG00000000465 AllianceGenome:RGD:1593280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ke4; ZIP7; Rt1Ke4; RT1-Ke4
Summary
Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including intracellular zinc ion homeostasis; regulation of ferroptosis; and zinc ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and nucleoplasm. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 280.8), Liver (RPKM 241.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc39a7 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4824967..4828431)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4823166..4826538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3819416..3822788, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class II, locus Hb, pseudogene 1 Neighboring gene collagen type XI alpha 2 chain Neighboring gene retinoid X receptor beta Neighboring gene hydroxysteroid (17-beta) dehydrogenase 8 Neighboring gene microRNA 219a-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. 25-Hydroxyvitamin D3 metabolism in vitro by mononuclear cells from hemodialysis patients. Reichel H, et al. Nephron, 1992. PMID 1300435
  2. Zn(2+)-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Tuncay E, et al. Mitochondrion, 2019 Jan. PMID 29307859
  3. Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Tuncay E, et al. Diabetes, 2017 May. PMID 28232492
  4. Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. Walter L, et al. Immunogenetics, 2000 Aug. PMID 10970097
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and sarco(endo)plasmic reticulum and contribute to cellular Zn(2+)-muffling between cellular-compartments in hyperglycemia or hypertrophic cardiomyocytes via affecting sarco(endo)plasmic reticulum-mitochondria coupling.
    Title: Zn(2+)-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.
  2. Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular cardiomyocytes from diabetic rats or high-glucose-treated H9c2 cells while ZnT7 expression was low. ZIP7 phosphorylation was increased in response to high glucose in vivo and in vitro.
    Title: Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94153

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ferroptosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in skin epidermis development ISO
Inferred from Sequence Orthology
more info
  
involved_in skin epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc transporter SLC39A7
Names
Histidine-rich membrane protein
RT1 class I, locus Ke4
RT1 region expressed gene KE4
solute carrier family 39 (zinc transporter), member 7
zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008885.2 → NP_001008885.1  zinc transporter SLC39A7 precursor

    See identical proteins and their annotated locations for NP_001008885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC079141
    UniProtKB/Swiss-Prot
    F7EQL7, Q6MGB4
    UniProtKB/TrEMBL
    A0A9M1WLR8
    Conserved Domains (1) summary
    pfam02535
    Location:126 → 445
    Zip; ZIP Zinc transporter

  2. NM_001164744.1 → NP_001158216.1  zinc transporter SLC39A7 precursor

    See identical proteins and their annotated locations for NP_001158216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC079141, DY547565
    UniProtKB/Swiss-Prot
    F7EQL7, Q6MGB4
    UniProtKB/TrEMBL
    A0A9M1WLR8
    Related
    ENSRNOP00000000541.6, ENSRNOT00000000541.9
    Conserved Domains (1) summary
    pfam02535
    Location:126 → 445
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4824967..4828431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279021.1 → XP_063135091.1  zinc transporter SLC39A7 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MGB4.1 GenPept UniProtKB/Swiss-Prot:Q6MGB4

Gene LinkOut

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