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Prrc2a proline-rich coiled-coil 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 294250, updated on 17-Aug-2024

Summary

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Official Symbol
Prrc2aprovided by RGD
Official Full Name
proline-rich coiled-coil 2Aprovided by RGD
Primary source
RGD:1303025
See related
EnsemblRapid:ENSRNOG00000000852 AllianceGenome:RGD:1303025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bat2
Summary
Predicted to be involved in cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 130.9), Spleen (RPKM 112.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prrc2a in Genome Data Viewer
Location:
20p12
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3660981..3686715)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3658391..3674143)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5139881..5155371, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene allograft inflammatory factor 1 Neighboring gene E230034O05Rik gene Neighboring gene small nucleolar RNA SNORA38 Neighboring gene BAG cochaperone 6 Neighboring gene apolipoprotein M Neighboring gene G4 protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. New polymorphic microsatellite markers in the human MHC class III region. Matsuzaka Y, et al. Tissue Antigens, 2001 May. PMID 11556964
  2. Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus. Hashimoto M, et al. Hum Genet, 1999 Sep. PMID 10987645
  3. BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. Piras IS, et al. Bone Marrow Transplant, 2014 Nov. PMID 25111513, Free PMC Article
  4. Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4. Urcelay E, et al. BMC Genomics, 2005 Apr 20. PMID 15842729, Free PMC Article
  5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein PRRC2A
Names
HLA-B-associated transcript 2
large proline-rich protein BAT2
proline-rich and coiled-coil-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212462.2 → NP_997627.1  protein PRRC2A

    See identical proteins and their annotated locations for NP_997627.1

    Status: VALIDATED

    Source sequence(s)
    BX883046
    UniProtKB/Swiss-Prot
    Q6MG48
    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3660981..3686715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098488.2 → XP_038954416.1  protein PRRC2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Conserved Domains (2) summary
    PHA03247
    Location:1189 → 1526
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 186
    BAT2_N; BAT2 N-terminus

  2. XM_063279001.1 → XP_063135071.1  protein PRRC2A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLV3

  3. XM_063279002.1 → XP_063135072.1  protein PRRC2A isoform X6

    UniProtKB/TrEMBL
    A0A0U1RRZ5, A0A8I5ZLV3
    Related
    ENSRNOP00000075873.2, ENSRNOT00000092322.3

  4. XM_006256051.5 → XP_006256113.1  protein PRRC2A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Related
    ENSRNOP00000001133.6, ENSRNOT00000001133.8
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

  5. XM_006256053.5 → XP_006256115.1  protein PRRC2A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

  6. XM_063279003.1 → XP_063135073.1  protein PRRC2A isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZLV3

  7. XM_006256048.5 → XP_006256110.1  protein PRRC2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Related
    ENSRNOP00000098146.1, ENSRNOT00000120486.2
    Conserved Domains (2) summary
    PHA03247
    Location:1189 → 1526
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 186
    BAT2_N; BAT2 N-terminus

  8. XM_006256050.5 → XP_006256112.1  protein PRRC2A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus

  9. XM_006256052.5 → XP_006256114.1  protein PRRC2A isoform X4

    See identical proteins and their annotated locations for XP_006256114.1

    UniProtKB/Swiss-Prot
    Q6MG48
    UniProtKB/TrEMBL
    A0A8I5ZLV3
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 187
    BAT2_N; BAT2 N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG48.1 GenPept UniProtKB/Swiss-Prot:Q6MG48

Gene LinkOut

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