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Actr1a actin related protein 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 294010, updated on 28-Oct-2024

Summary

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Official Symbol
Actr1aprovided by RGD
Official Full Name
actin related protein 1Aprovided by RGD
Primary source
RGD:1307025
See related
EnsemblRapid:ENSRNOG00000019725 AllianceGenome:RGD:1307025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity. Involved in spermatogenesis. Located in COPI-coated vesicle; centriole; and manchette. Orthologous to human ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 502.3), Heart (RPKM 416.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Actr1a in Genome Data Viewer
Location:
1q54
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255179241..255199009, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245237821..245256618, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266123864..266142621, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 10 open reading frame 95 Neighboring gene microRNA 146b Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene uncharacterized LOC134484078 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene uncharacterized LOC134484077

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Application of serex-analysis for identification of human colon cancer antigens. Garifulin OM, et al. Exp Oncol, 2015 Sep. PMID 26422100
  2. Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain. Gulesserian T, et al. Biochem Biophys Res Commun, 2002 Feb 15. PMID 11829462
  3. ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. Fouquet J, et al. J Cell Sci, 2000 Mar. PMID 10671377
  4. Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles. Heimann K, et al. J Biol Chem, 1999 Apr 16. PMID 10196146
  5. Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Kiyomitsu T, et al. Nat Cell Biol, 2012 Feb 12. PMID 22327364, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-centractin
Names
ARP1 actin related protein 1 homolog A
ARP1 actin-related protein 1 homolog A, centractin alpha
centractin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106364.1 → NP_001099834.1  alpha-centractin

    See identical proteins and their annotated locations for NP_001099834.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473986
    UniProtKB/Swiss-Prot
    P85515
    UniProtKB/TrEMBL
    A0A8I6A4H6, A6JHM5
    Related
    ENSRNOP00000109332.1, ENSRNOT00000126408.1
    Conserved Domains (1) summary
    cl17037
    Location:5 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255179241..255199009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287265.1 → XP_063143335.1  alpha-centractin isoform X3

    UniProtKB/Swiss-Prot
    P85515
    UniProtKB/TrEMBL
    A6JHM5

  2. XM_063287262.1 → XP_063143332.1  alpha-centractin isoform X2

  3. XM_006231470.5 → XP_006231532.1  alpha-centractin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H6
    Conserved Domains (1) summary
    cl17037
    Location:5 → 396
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_039109087.2 → XP_038965015.1  alpha-centractin isoform X4

    UniProtKB/TrEMBL
    A0A8L2UK87
    Related
    ENSRNOP00000026792.7, ENSRNOT00000026792.7
    Conserved Domains (1) summary
    cl17037
    Location:5 → 307
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P85515.1 GenPept UniProtKB/Swiss-Prot:P85515

Gene LinkOut

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