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B3gat3 beta-1,3-glucuronyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293722, updated on 14-Nov-2024

Summary

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Official Symbol
B3gat3provided by RGD
Official Full Name
beta-1,3-glucuronyltransferase 3provided by RGD
Primary source
RGD:1311968
See related
EnsemblRapid:ENSRNOG00000019873 AllianceGenome:RGD:1311968
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Predicted to be involved in several processes, including chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of intracellular protein transport. Predicted to act upstream of or within dermatan sulfate proteoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 367.5), Kidney (RPKM 180.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B3gat3 in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215246453..215253033)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205817374..205823928)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225120061..225126579)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551607 Neighboring gene integrator complex subunit 5 Neighboring gene glucosidase II alpha subunit Neighboring gene retinal outer segment membrane protein 1 Neighboring gene EMAP like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GlcAT-I has a role in controlling and reversing articular cartilage defects
    Title: Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC188078

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dermatan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dermatan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Names
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
NP_001121656.1
XP_038964511.1
XP_063142988.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128184.1 → NP_001121656.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

    See identical proteins and their annotated locations for NP_001121656.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6AFX5, B2GV35, B5DEK9
    Related
    ENSRNOP00000105268.1, ENSRNOT00000173965.1
    Conserved Domains (1) summary
    cd00218
    Location:75 → 313
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215246453..215253033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108583.2 → XP_038964511.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:75 → 206
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_063286918.1 → XP_063142988.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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