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Cdc42bpg CDC42 binding protein kinase gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 293693, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc42bpgprovided by RGD
Official Full Name
CDC42 binding protein kinase gammaprovided by RGD
Primary source
RGD:1307260
See related
EnsemblRapid:ENSRNOG00000027456 AllianceGenome:RGD:1307260
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307260
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and protein phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 154.7), Kidney (RPKM 110.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc42bpg in Genome Data Viewer
Location:
1q43
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213037603..213057764)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203608339..203628502)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221673334..221693518)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene microRNA 192 Neighboring gene EH-domain containing 1 Neighboring gene uncharacterized LOC134483959 Neighboring gene menin 1 Neighboring gene mitogen activated protein kinase kinase kinase kinase 2 Neighboring gene uncharacterized LOC134483960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. Ng Y, et al. J Biol Chem, 2004 Aug 13. PMID 15194684
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
NP_001123485.1
XP_006230813.1
XP_038964401.1
XP_038964412.1
XP_038964415.1
XP_038964426.1
XP_063142946.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130013.1 → NP_001123485.1  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_001123485.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HZG0
    Conserved Domains (6) summary
    pfam08826
    Location:744 → 799
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:938 → 1070
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:879 → 927
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1097 → 1360
    CNH; CNH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213037603..213057764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108498.2 → XP_038964426.1  serine/threonine-protein kinase MRCK gamma isoform X5

    Conserved Domains (5) summary
    cd01243
    Location:846 → 978
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:352 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1005 → 1268
    CNH; CNH domain
    cd20866
    Location:787 → 838
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  2. XM_063286876.1 → XP_063142946.1  serine/threonine-protein kinase MRCK gamma isoform X6

  3. XM_039108487.2 → XP_038964415.1  serine/threonine-protein kinase MRCK gamma isoform X3

    Conserved Domains (5) summary
    cd01243
    Location:943 → 1075
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:450 → 809
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1102 → 1365
    CNH; CNH domain
    cd20866
    Location:884 → 935
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  4. XM_039108473.1 → XP_038964401.1  serine/threonine-protein kinase MRCK gamma isoform X1

    Conserved Domains (5) summary
    cd01243
    Location:944 → 1076
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:450 → 809
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1103 → 1366
    CNH; CNH domain
    cd20866
    Location:885 → 936
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  5. XM_039108484.1 → XP_038964412.1  serine/threonine-protein kinase MRCK gamma isoform X2

    Related
    ENSRNOP00000029466.7, ENSRNOT00000038016.7
    Conserved Domains (5) summary
    cd01243
    Location:944 → 1076
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:450 → 809
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1103 → 1366
    CNH; CNH domain
    cd20866
    Location:885 → 936
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  6. XM_006230751.5 → XP_006230813.1  serine/threonine-protein kinase MRCK gamma isoform X4

    UniProtKB/TrEMBL
    D3Z837
    Related
    ENSRNOP00000108240.1, ENSRNOT00000135588.1
    Conserved Domains (6) summary
    pfam08826
    Location:744 → 799
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:938 → 1070
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:879 → 927
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1097 → 1360
    CNH; CNH domain
Nucleotide Protein Strain
Heading Accession and Version

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