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Tm7sf2 transmembrane 7 superfamily member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293688, updated on 2-Nov-2024

Summary

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Official Symbol
Tm7sf2provided by RGD
Official Full Name
transmembrane 7 superfamily member 2provided by RGD
Primary source
RGD:1311205
See related
EnsemblRapid:ENSRNOG00000020989 AllianceGenome:RGD:1311205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable delta14-sterol reductase activity. Predicted to be involved in cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and organelle membrane. Predicted to be part of receptor complex. Predicted to be active in endoplasmic reticulum membrane and nuclear inner membrane. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 396.2), Kidney (RPKM 72.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Tm7sf2 in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212785217..212789572, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203355930..203360287, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221426017..221430340, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion Neighboring gene zinc finger, HIT-type containing 2 Neighboring gene VPS51 subunit of GARP complex Neighboring gene microRNA 6315 Neighboring gene transmembrane protein 262 Neighboring gene zinc finger protein-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tm7sf2 may participate in the healing of burn wounds. Lei N, et al. Mol Med Rep, 2016 Jul. PMID 27220550
  2. Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. Bennati AM, et al. FEBS J, 2008 Oct. PMID 18785926
  3. Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Bennati AM, et al. Biochim Biophys Acta, 2006 Jul. PMID 16784888
  4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108990

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables delta14-sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta14-sterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
delta(14)-sterol reductase TM7SF2
Names
delta(14)-sterol reductase
NP_001013089.1
XP_038964368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013071.1 → NP_001013089.1  delta(14)-sterol reductase TM7SF2

    See identical proteins and their annotated locations for NP_001013089.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091237
    UniProtKB/TrEMBL
    A0A8I5ZP05, A6HZC6, F7FG10, Q5BK21
    Related
    ENSRNOP00000028485.3, ENSRNOT00000028485.8
    Conserved Domains (1) summary
    cl21511
    Location:8 → 418
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212785217..212789572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108440.2 → XP_038964368.1  delta(14)-sterol reductase TM7SF2 isoform X1

    Conserved Domains (1) summary
    cl21511
    Location:1 → 290
    PEMT; Phospholipid methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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