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Phlda2 pleckstrin homology-like domain, family A, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293637, updated on 18-Sep-2024

Summary

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Official Symbol
Phlda2provided by RGD
Official Full Name
pleckstrin homology-like domain, family A, member 2provided by RGD
Primary source
RGD:1304755
See related
AllianceGenome:RGD:1304755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in placenta development. Predicted to act upstream of or within several processes, including regulation of glycogen metabolic process; regulation of growth hormone activity; and regulation of spongiotrophoblast cell proliferation. Predicted to be located in cytoplasm. Orthologous to human PHLDA2 (pleckstrin homology like domain family A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 15.6), Liver (RPKM 4.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Phlda2 in Genome Data Viewer
Location:
1q42
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208126302..208127241, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198696897..198699292, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216701345..216704479, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 1C Neighboring gene solute carrier family 22, member 18 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC134483952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Placental overgrowth in mice lacking the imprinted gene Ipl. Frank D, et al. Proc Natl Acad Sci U S A, 2002 May 28. PMID 12032310, Free PMC Article
  2. The imprinted Phlda2 gene regulates extraembryonic energy stores. Tunster SJ, et al. Mol Cell Biol, 2010 Jan. PMID 19884348, Free PMC Article
  3. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in placenta development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of growth hormone activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology-like domain family A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100521.1 → NP_001093991.1  pleckstrin homology-like domain family A member 2 isoform 1

    See identical proteins and their annotated locations for NP_001093991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0T2W6, A6HYC0, F1LME7
    Conserved Domains (2) summary
    smart00233
    Location:12 → 102
    PH; Pleckstrin homology domain
    pfam00169
    Location:12 → 102
    PH; PH domain

  2. NM_001170480.1 → NP_001163951.1  pleckstrin homology-like domain family A member 2 isoform 2

    See identical proteins and their annotated locations for NP_001163951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HYB9
    Conserved Domains (1) summary
    smart00233
    Location:12 → 102
    PH; Pleckstrin homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208126302..208127241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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