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Pidd1 p53-induced death domain protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293625, updated on 18-Sep-2024

Summary

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Symbol
Pidd1provided by RGD
Full Name
p53-induced death domain protein 1provided by RGD
Primary source
RGD:1311792
See related
EnsemblRapid:ENSRNOG00000049179 AllianceGenome:RGD:1311792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrdd; Pidd
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of cysteine-type endopeptidase activity involved in apoptotic process; and protein autoprocessing. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 27.6), Spleen (RPKM 22.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pidd1 in Genome Data Viewer
Location:
1q41
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205966392..205972359, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196536815..196542808, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214418751..214423959, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene solute carrier family 25 member 22 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression and role of PIDD in retina after optic nerve crush. Tang F, et al. J Mol Histol, 2020 Feb. PMID 32065357
  2. Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush. Zhang M, et al. Curr Mol Med, 2019. PMID 31533600
  3. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. Tinel A, et al. EMBO J, 2007 Jan 10. PMID 17159900, Free PMC Article
  4. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver TG, et al. Mol Cell, 2011 Jul 8. PMID 21726810, Free PMC Article
  5. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Berube C, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183742, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
    Title: Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
  2. The expression and role of PIDD in retina after optic nerve crush.
    Title: The expression and role of PIDD in retina after optic nerve crush.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of endopeptidase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
p53-induced death domain-containing protein 1
Names
leucine-rich repeats and death domain containing
p53-induced protein with a death domain-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106318.2 → NP_001099788.2  p53-induced death domain-containing protein 1

    See identical proteins and their annotated locations for NP_001099788.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    M0R797
    Related
    ENSRNOP00000065320.1, ENSRNOT00000072774.3
    Conserved Domains (5) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd08779
    Location:795 → 880
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205966392..205972359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107985.2 → XP_038963913.1  p53-induced death domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    M0R797
    Conserved Domains (5) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd08779
    Location:795 → 880
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain

  2. XM_039108000.2 → XP_038963928.1  p53-induced death domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd08779
    Location:779 → 864
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain

  3. XM_039107978.2 → XP_038963906.1  p53-induced death domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    M0R797
    Conserved Domains (5) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd08779
    Location:795 → 880
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain

  4. XM_039107989.2 → XP_038963917.1  p53-induced death domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    M0R797
    Conserved Domains (5) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd08779
    Location:795 → 880
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain

  5. XM_039108008.2 → XP_038963936.1  p53-induced death domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A6HXX6
    Conserved Domains (3) summary
    cd08779
    Location:477 → 562
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    pfam10461
    Location:110 → 142
    Peptidase_S68; Peptidase S68
    cl02517
    Location:12 → 85
    ZU5; ZU5 domain

  6. XM_063286610.1 → XP_063142680.1  p53-induced death domain-containing protein 1 isoform X3

  7. XM_039108007.2 → XP_038963935.1  p53-induced death domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    COG4886
    Location:135 → 296
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:132 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:428 → 460
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330 → 403
    ZU5; ZU5 domain
Nucleotide Protein Strain
Heading Accession and Version

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