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Palb2 partner and localizer of BRCA2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293452, updated on 17-Aug-2024

Summary

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Official Symbol
Palb2provided by RGD
Official Full Name
partner and localizer of BRCA2provided by RGD
Primary source
RGD:1304759
See related
EnsemblRapid:ENSRNOG00000025126 AllianceGenome:RGD:1304759
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304759
Summary
Predicted to enable DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within several processes, including animal organ development; chordate embryonic development; and post-anal tail morphogenesis. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; breast cancer; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 37.7), Spleen (RPKM 30.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Palb2 in Genome Data Viewer
Location:
1q36
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (186096312..186120284, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (176665076..176689053, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (192064586..192088547, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin family domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1 Neighboring gene dynactin subunit 5 Neighboring gene polo-like kinase 1 Neighboring gene endoplasmic reticulum to nucleus signaling 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Jones S, et al. Science, 2009 Apr 10. PMID 19264984, Free PMC Article
  2. PALB2 regulates recombinational repair through chromatin association and oligomerization. Sy SM, et al. J Biol Chem, 2009 Jul 3. PMID 19423707, Free PMC Article
  3. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Dray E, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20871616, Free PMC Article
  4. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, et al. Int J Cancer, 2019 Apr 15. PMID 30303537, Free PMC Article
  5. Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression. Bouwman P, et al. J Pathol, 2011 May. PMID 21404276

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-anal tail morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
partner and localizer of BRCA2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191603.1 → NP_001178532.1  partner and localizer of BRCA2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5Y7Q7, D3ZM14
    Related
    ENSRNOP00000041446.4, ENSRNOT00000047420.7
    Conserved Domains (1) summary
    pfam16756
    Location:761 → 1108
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    186096312..186120284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759712.4 → XP_008757934.1  partner and localizer of BRCA2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y7Q7
    Related
    ENSRNOP00000111776.1, ENSRNOT00000146928.1
    Conserved Domains (1) summary
    pfam16756
    Location:759 → 1084
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

  2. XM_008759713.3 → XP_008757935.1  partner and localizer of BRCA2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y7Q7
    Conserved Domains (1) summary
    pfam16756
    Location:761 → 1054
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

  3. XM_039107112.2 → XP_038963040.1  partner and localizer of BRCA2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y7Q7
    Conserved Domains (1) summary
    pfam16756
    Location:761 → 1107
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

  4. XM_008759711.4 → XP_008757933.1  partner and localizer of BRCA2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y7Q7
    Related
    ENSRNOP00000077610.2, ENSRNOT00000113438.2
    Conserved Domains (1) summary
    pfam16756
    Location:754 → 1101
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

RNA

  1. XR_005503165.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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