Tjp1 tight junction protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tjp1provided by RGD
Official Full Name: tight junction protein 1provided by RGD
Primary source: RGD:1306305
See related: EnsemblRapid:ENSRNOG00000011077 AllianceGenome:RGD:1306305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZO-1
Summary: Enables protein C-terminus binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to lipopolysaccharide. Located in bicellular tight junction; cytoplasm; and gap junction. Biomarker of several diseases, including brain ischemia; cholestasis; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 429.5), Heart (RPKM 238.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q22

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (128260330..128505018, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (118849838..119094492, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (126146489..126515359, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.
Title: VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Title: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
Title: Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
Title: The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
Title: Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
The HIF-1alpha positively regulates the expression of MLCK and p-MLC and negatively regulates the expression of ZO-1 in rat monolayer endothelial cells.
Title: Effects of hypoxia inducible factor-1α on expression levels of MLCK, p-MLC and ZO-1 of rat endothelial cells.
we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels.
Title: Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats.
This study identified that Cd induces a reactive oxygen species -dependent endoplasmic reticulum stress-mediated signaling pathway involving caspase-3 activation that triggers ATP release by a PANX1 channel-independent mechanism, leading to structural morphologic alterations of the ZO-1 TJ component in a rat brain endothelial cell line (RBE4), a well-characterized and widely used Blood Brain Barrier model.
Title: Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier.
High-glucose exposure in early reperfusion causes blood-brain barrier disruption, with MMP-2/9-mediated extracellular degradation, caveolin-1-mediated intracellular translocation and autophagy-lysosome-mediated degradation of ZO-1 protein all together involved in the process. The role of MMP-2/-9 and autophagy in the modulation of paracellular permeability was confirmed by pharmacological inhibition.
Title: Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood-Brain Barrier Permeability During Early Reperfusion in Stroke.
We labeled brain with ZO1, vimentin, pan-cadherin and angiotensin II type 1 receptors markers which showed a morphologically distinct population of cells at the region of the sulcus medianus organum similar to tanycytes present in the median eminence, a known circumventricular organ.
Title: Expression of ZO1, vimentin, pan-cadherin and AGTR1 in tanycyte-like cells of the sulcus medianus organum.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

TJP1 (e-PCR)
- UniSTS:479948

TJP1 (e-PCR)
- UniSTS:144631

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144631

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144632

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144634

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144635

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables connexin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in adherens junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in ameloblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to bicellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnetism	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: tight junction protein ZO-1

Names: zona occludens 1; zona occludens protein 1; zonula occludens protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106266.1 → NP_001099736.1 tight junction protein ZO-1

See identical proteins and their annotated locations for NP_001099736.1

Status: PROVISIONAL

Source sequence(s)

CH473980

UniProtKB/TrEMBL

A6JBM5, F1M4A0

Related

ENSRNOP00000014988.7, ENSRNOT00000014988.9

Conserved Domains (6) summary

smart00218
Location:1617 → 1723

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:505 → 569

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:603 → 782

GuKc; Guanylate kinase homologues

smart00228
Location:171 → 251

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:413 → 489

PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

128260330..128505018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105296.2 → XP_038961224.1 tight junction protein ZO-1 isoform X6

UniProtKB/TrEMBL

F1M4A0

Conserved Domains (7) summary

smart00218
Location:1722 → 1828

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1052 → 1659

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_039105288.2 → XP_038961216.1 tight junction protein ZO-1 isoform X5

UniProtKB/TrEMBL

A0A8I6AFQ2

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1052 → 1659

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1725 → 1814

ZU5; ZU5 domain
XM_017588935.3 → XP_017444424.1 tight junction protein ZO-1 isoform X3

UniProtKB/TrEMBL

A0A8I6AFQ2
XM_039105279.2 → XP_038961207.1 tight junction protein ZO-1 isoform X4

UniProtKB/TrEMBL

A0A8I6AFQ2

Conserved Domains (7) summary

smart00218
Location:1739 → 1845

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1265 → 1691

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_039105265.2 → XP_038961193.1 tight junction protein ZO-1 isoform X2

UniProtKB/TrEMBL

A0A8I6AFQ2

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1265 → 1691

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1742 → 1831

ZU5; ZU5 domain
XM_039105261.2 → XP_038961189.1 tight junction protein ZO-1 isoform X1

UniProtKB/TrEMBL

A0A8I6AFQ2

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1265 → 1691

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1742 → 1841

ZU5; ZU5 domain
XM_039105346.2 → XP_038961274.1 tight junction protein ZO-1 isoform X14

UniProtKB/TrEMBL

A0A8I6AFQ2

Related

ENSRNOP00000093370.2, ENSRNOT00000096674.2

Conserved Domains (7) summary

smart00218
Location:1642 → 1748

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1185 → 1594

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_063284353.1 → XP_063140423.1 tight junction protein ZO-1 isoform X13
XM_039105338.2 → XP_038961266.1 tight junction protein ZO-1 isoform X11

UniProtKB/TrEMBL

A0A8I6AFQ2

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1185 → 1594

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1645 → 1744

ZU5; ZU5 domain
XM_039105314.2 → XP_038961242.1 tight junction protein ZO-1 isoform X8

UniProtKB/TrEMBL

A0A8I6AFQ2

Related

ENSRNOP00000109784.1, ENSRNOT00000146483.1

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1185 → 1611

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1662 → 1761

ZU5; ZU5 domain
XM_039105302.1 → XP_038961230.1 tight junction protein ZO-1 isoform X7

UniProtKB/TrEMBL

A0A8L2R644

Conserved Domains (7) summary

cd12026
Location:553 → 617

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:651 → 830

GuKc; Guanylate kinase homologues

smart00228
Location:219 → 299

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1208 → 1634

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:58 → 143

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:461 → 537

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1685 → 1784

ZU5; ZU5 domain
XM_039105332.2 → XP_038961260.1 tight junction protein ZO-1 isoform X10

UniProtKB/TrEMBL

A0A8L2R644

Conserved Domains (7) summary

cd12026
Location:516 → 580

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:614 → 793

GuKc; Guanylate kinase homologues

smart00228
Location:182 → 262

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1171 → 1597

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:21 → 106

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:424 → 500

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1648 → 1747

ZU5; ZU5 domain
XM_063284370.1 → XP_063140440.1 tight junction protein ZO-1 isoform X19
XM_063284364.1 → XP_063140434.1 tight junction protein ZO-1 isoform X18
XM_063284361.1 → XP_063140431.1 tight junction protein ZO-1 isoform X17
XM_063284360.1 → XP_063140430.1 tight junction protein ZO-1 isoform X16

Related

ENSRNOP00000078542.2, ENSRNOT00000112594.2
XM_063284358.1 → XP_063140428.1 tight junction protein ZO-1 isoform X15
XM_063284350.1 → XP_063140420.1 tight junction protein ZO-1 isoform X12

UniProtKB/Swiss-Prot

A0A0G2K2P5
XM_039105325.2 → XP_038961253.1 tight junction protein ZO-1 isoform X9

UniProtKB/TrEMBL

A0A8L2R644

Conserved Domains (7) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1172 → 1598

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1649 → 1748

ZU5; ZU5 domain