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Dpp6 dipeptidyl peptidase like 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29272, updated on 17-Aug-2024

Summary

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Official Symbol
Dpp6provided by RGD
Official Full Name
dipeptidyl peptidase like 6provided by RGD
Primary source
RGD:68402
See related
EnsemblRapid:ENSRNOG00000030547 AllianceGenome:RGD:68402
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DPP VI
Summary
Predicted to enable potassium channel regulator activity. Involved in positive regulation of potassium ion transport and positive regulation of protein localization to plasma membrane. Located in cell surface and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 198.4) and Adrenal (RPKM 21.9) See more
Orthologs
human mouse all
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Genomic context

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See Dpp6 in Genome Data Viewer
Location:
4q11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (8323220..9242694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (7589386..8508666, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (4021021..4943675, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene transfer RNA valine (anticodon AAC) 11 Neighboring gene uncharacterized LOC134486537 Neighboring gene PAX interacting protein 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 89 Neighboring gene uncharacterized LOC120102469 Neighboring gene 60S ribosomal protein L10a pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 4, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients. Del Bo R, et al. J Neurol Neurosurg Psychiatry, 2008 Sep. PMID 18708572
  2. Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells. Jerng HH, et al. PLoS One, 2012. PMID 22675523, Free PMC Article
  3. Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients. Li XG, et al. Chin Med J (Engl), 2009 Dec 20. PMID 20137488
  4. Dpp6 is associated with susceptibility to progressive spinal muscular atrophy. van Es MA, et al. Neurology, 2009 Mar 31. PMID 19332697
  5. Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, et al. Am J Hum Genet, 2009 Apr. PMID 19285295, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.
    Title: DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.
  2. The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
    Title: Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
  3. a novel component of A-type K(+) channels
    Title: The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables dipeptidyl-peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-type potassium channel modulatory protein DPP6; dipeptidyl aminopeptidase-like protein 6
Names
DPPX
dipeptidyl aminopeptidase-related protein
dipeptidyl peptidase IV-like protein
dipeptidyl peptidase VI
dipeptidylpeptidase 6
dipeptidylpeptidase VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022850.2 → NP_074041.2  A-type potassium channel modulatory protein DPP6

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P46101
    UniProtKB/TrEMBL
    A0A8I6A0E2
    Related
    ENSRNOP00000084952.1, ENSRNOT00000108476.2
    Conserved Domains (2) summary
    pfam00930
    Location:189 → 555
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:635 → 844
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    8323220..9242694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592501.3 → XP_017447990.1  dipeptidyl aminopeptidase-like protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQR2, A6KJK3
    Related
    ENSRNOP00000080650.1, ENSRNOT00000117212.2
    Conserved Domains (2) summary
    pfam00930
    Location:134 → 500
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:580 → 789
    Abhydrolase; alpha/beta hydrolases

  2. XM_017592503.3 → XP_017447992.1  dipeptidyl aminopeptidase-like protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZR04, A6KJK3
    Related
    ENSRNOP00000080741.1, ENSRNOT00000093848.2
    Conserved Domains (2) summary
    pfam00930
    Location:131 → 497
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:577 → 786
    Abhydrolase; alpha/beta hydrolases

  3. XM_017592504.3 → XP_017447993.1  dipeptidyl aminopeptidase-like protein 6 isoform X4

    UniProtKB/TrEMBL
    A6KJK3

  4. XM_006235880.5 → XP_006235942.1  dipeptidyl aminopeptidase-like protein 6 isoform X2

    UniProtKB/TrEMBL
    A6KJK3, F1LMR7
    Related
    ENSRNOP00000043113.2, ENSRNOT00000045773.4
    Conserved Domains (2) summary
    pfam00930
    Location:133 → 499
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:579 → 788
    Abhydrolase; alpha/beta hydrolases

  5. XM_063285681.1 → XP_063141751.1  dipeptidyl aminopeptidase-like protein 6 isoform X5

  6. XM_063285682.1 → XP_063141752.1  dipeptidyl aminopeptidase-like protein 6 isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46101.1 GenPept UniProtKB/Swiss-Prot:P46101

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