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Cmip c-Maf-inducing protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 292051, updated on 2-Nov-2024

Summary

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Official Symbol
Cmipprovided by RGD
Official Full Name
c-Maf-inducing proteinprovided by RGD
Primary source
RGD:1306101
See related
EnsemblRapid:ENSRNOG00000013178 AllianceGenome:RGD:1306101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
c-Mip; RGD1306101
Summary
Predicted to act upstream of or within in utero embryonic development. Predicted to be active in cytosol and nucleoplasm. Orthologous to human CMIP (c-Maf inducing protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 69.5), Kidney (RPKM 61.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmip in Genome Data Viewer
Location:
19q12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (62213402..62419443)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45304597..45510653)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49792273..50000535)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene gigaxonin Neighboring gene transfer RNA serine (anticodon AGA) 23 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated like 1 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene uncharacterized LOC102548350 Neighboring gene uncharacterized LOC120098622 Neighboring gene phospholipase C, gamma 2 Neighboring gene uncharacterized LOC120098492 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization. Yu L, et al. Mol Med Rep, 2017 Oct. PMID 28791377
  2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CMIP inhibits cofilin1 activity and alters podocyte cytoskeleton organization at least through RhoA signaling in PAinduced podocyte injury
    Title: c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C-Maf-inducing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163273.1 → NP_001156745.1  C-Maf-inducing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2JYB9, A0A8I6A9M1
    Related
    ENSRNOP00000070595.2, ENSRNOT00000083991.3
    Conserved Domains (3) summary
    cd09293
    Location:594 → 768
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:664 → 687
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00169
    Location:71 → 157
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    62213402..62419443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277945.1 → XP_063134015.1  C-Maf-inducing protein isoform X1

    UniProtKB/TrEMBL
    A6IZH3

  2. XM_006255684.5 → XP_006255746.1  C-Maf-inducing protein isoform X2

    See identical proteins and their annotated locations for XP_006255746.1

    UniProtKB/TrEMBL
    F1M8D3
    Conserved Domains (2) summary
    cd09293
    Location:476 → 615
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:511 → 534
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_039097643.2 → XP_038953571.1  C-Maf-inducing protein isoform X3

    UniProtKB/TrEMBL
    F1M8D3
    Conserved Domains (2) summary
    cd09293
    Location:442 → 581
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:477 → 500
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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