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Iws1 interacts with SUPT6H, CTD assembly factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291705, updated on 10-Oct-2024

Summary

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Official Symbol
Iws1provided by RGD
Official Full Name
interacts with SUPT6H, CTD assembly factor 1provided by RGD
Primary source
RGD:1304762
See related
EnsemblRapid:ENSRNOG00000014630 AllianceGenome:RGD:1304762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304762
Summary
Predicted to be involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of histone modification; and regulation of mRNA export from nucleus. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 178.4), Spleen (RPKM 130.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iws1 in Genome Data Viewer
Location:
18p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23969352..24011560)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23695496..23737363)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24849508..24891339)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 2 Neighboring gene myosin VIIb Neighboring gene uncharacterized LOC134482980 Neighboring gene POTE ankyrin domain family, member F Neighboring gene uncharacterized LOC134482924 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Yoh SM, et al. Genes Dev, 2008 Dec 15. PMID 19141475, Free PMC Article
  2. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Yoh SM, et al. Genes Dev, 2007 Jan 15. PMID 17234882, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124986

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein IWS1 homolog
Names
IWS1 homolog
IWS1, SUPT6H interacting protein
IWS1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034918.2 → NP_001030090.1  protein IWS1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001030090.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q3SWT4
    UniProtKB/TrEMBL
    A0A0G2JWE3
    Related
    ENSRNOP00000057730.2, ENSRNOT00000061011.5
    Conserved Domains (2) summary
    PHA02664
    Location:232 → 341
    PHA02664; hypothetical protein; Provisional
    cl00146
    Location:474 → 723
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. NM_001398635.1 → NP_001385564.1  protein IWS1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000085053.2, ENSRNOT00000102322.2
    Conserved Domains (2) summary
    COG5271
    Location:30 → 402
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl00146
    Location:474 → 738
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    23969352..24011560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254574.5 → XP_006254636.1  protein IWS1 homolog isoform X5

    UniProtKB/TrEMBL
    A0A8I6A2E0, A0A8I6AF19
    Related
    ENSRNOP00000091736.1, ENSRNOT00000112252.2
    Conserved Domains (2) summary
    PHA02664
    Location:232 → 341
    PHA02664; hypothetical protein; Provisional
    cl00146
    Location:474 → 725
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. XM_017600919.3 → XP_017456408.1  protein IWS1 homolog isoform X4

    UniProtKB/TrEMBL
    A0A8I6A2E0, A0A8I6AB64
    Related
    ENSRNOP00000069847.3, ENSRNOT00000085516.3

  3. XM_006254573.5 → XP_006254635.1  protein IWS1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWE3
    Conserved Domains (2) summary
    PHA02664
    Location:232 → 341
    PHA02664; hypothetical protein; Provisional
    cl00146
    Location:473 → 737
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  4. XM_006254572.5 → XP_006254634.1  protein IWS1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006254634.1

    UniProtKB/Swiss-Prot
    Q3SWT4
    UniProtKB/TrEMBL
    A0A0G2JWE3
    Conserved Domains (2) summary
    PHA02664
    Location:232 → 341
    PHA02664; hypothetical protein; Provisional
    cl00146
    Location:474 → 723
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  5. XM_063277254.1 → XP_063133324.1  protein IWS1 homolog isoform X3

RNA

  1. XR_005496012.2 RNA Sequence

  2. XR_005496013.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SWT4.1 GenPept UniProtKB/Swiss-Prot:Q3SWT4

Gene LinkOut

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