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Trim36 tripartite motif-containing 36 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291597, updated on 2-Nov-2024

Summary

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Official Symbol
Trim36provided by RGD
Official Full Name
tripartite motif-containing 36provided by RGD
Primary source
RGD:1308714
See related
EnsemblRapid:ENSRNOG00000016612 AllianceGenome:RGD:1308714
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-tubulin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including acrosome reaction; regulation of microtubule cytoskeleton organization; and spindle organization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in acrosomal vesicle. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human TRIM36 (tripartite motif containing 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 35.7), Brain (RPKM 25.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trim36 in Genome Data Viewer
Location:
18q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41047657..41099497, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (38859604..38912859, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40081028..40134673, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27a, pseudogene 13 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L31 like 16 Neighboring gene uncharacterized LOC120098337 Neighboring gene protein geranylgeranyltransferase type I subunit beta Neighboring gene uncharacterized LOC134483014 Neighboring gene coiled-coil domain containing 112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family. Singh N, et al. Hum Mol Genet, 2017 Mar 15. PMID 28087737
  2. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. Kitamura K, et al. J Biol Chem, 2003 Nov 7. PMID 12917430
  3. TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression. Miyajima N, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232519
  4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM36
Names
tripartite motif protein 36
NP_001099617.1
XP_006254748.1
XP_038952628.1
XP_038952629.1
XP_038952630.1
XP_038952631.1
XP_063133283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106147.1 → NP_001099617.1  E3 ubiquitin-protein ligase TRIM36

    See identical proteins and their annotated locations for NP_001099617.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/TrEMBL
    A0A8I5ZKQ5, A6IWV0, F1LY63
    Related
    ENSRNOP00000022294.6, ENSRNOT00000022294.9
    Conserved Domains (5) summary
    smart00060
    Location:431 → 494
    FN3; Fibronectin type 3 domain
    cd00021
    Location:211 → 249
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:33 → 61
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:516 → 719
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:256 → 380
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    41047657..41099497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254686.5 → XP_006254748.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW11, A0A8I5ZKQ5
    Related
    ENSRNOP00000110746.1, ENSRNOT00000155574.1
    Conserved Domains (5) summary
    smart00060
    Location:419 → 482
    FN3; Fibronectin type 3 domain
    cd00021
    Location:199 → 237
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:21 → 49
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:504 → 707
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:244 → 368
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_039096700.2 → XP_038952628.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

    Conserved Domains (7) summary
    smart00502
    Location:244 → 368
    BBC; B-Box C-terminal domain
    smart00060
    Location:419 → 482
    FN3; Fibronectin type 3 domain
    cd16756
    Location:16 → 113
    RING-HC_TRIM36; RING finger, HC subclass, found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    cd19778
    Location:198 → 242
    Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    cd19848
    Location:139 → 193
    Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    pfam18568
    Location:347 → 395
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:504 → 560
    SPRY; SPRY domain

  3. XM_063277213.1 → XP_063133283.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

  4. XM_039096703.2 → XP_038952631.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

    Conserved Domains (4) summary
    smart00502
    Location:2 → 96
    BBC; B-Box C-terminal domain
    smart00060
    Location:147 → 210
    FN3; Fibronectin type 3 domain
    cd12894
    Location:232 → 435
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    pfam18568
    Location:75 → 123
    COS; TRIM C-terminal subgroup One Signature domain

  5. XM_039096702.2 → XP_038952630.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

    Conserved Domains (4) summary
    smart00502
    Location:2 → 96
    BBC; B-Box C-terminal domain
    smart00060
    Location:147 → 210
    FN3; Fibronectin type 3 domain
    cd12894
    Location:232 → 435
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    pfam18568
    Location:75 → 123
    COS; TRIM C-terminal subgroup One Signature domain

  6. XM_039096701.2 → XP_038952629.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

    Conserved Domains (6) summary
    smart00502
    Location:244 → 368
    BBC; B-Box C-terminal domain
    smart00060
    Location:419 → 482
    FN3; Fibronectin type 3 domain
    cd16756
    Location:16 → 113
    RING-HC_TRIM36; RING finger, HC subclass, found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    cd19778
    Location:198 → 242
    Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    cd19848
    Location:139 → 193
    Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
    pfam18568
    Location:347 → 395
    COS; TRIM C-terminal subgroup One Signature domain
Nucleotide Protein Strain
Heading Accession and Version

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