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Psmg2 proteasome assembly chaperone 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291539, updated on 17-Aug-2024

Summary

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Official Symbol
Psmg2provided by RGD
Official Full Name
proteasome assembly chaperone 2provided by RGD
Primary source
RGD:1304867
See related
AllianceGenome:RGD:1304867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnfsf5ip1
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly and proteasome assembly. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and negative regulation of apoptotic process. Predicted to be part of chaperone complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 98.9), Thymus (RPKM 92.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63478620..63493193)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61208669..61227671)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63394991..63420491)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene spire-type actin nucleation factor 1 Neighboring gene centrosomal protein 76 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene uncharacterized LOC134482957 Neighboring gene thymosin, beta 10 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. Bahar R, et al. J Biol Chem, 2002 Oct 18. PMID 12147697
  2. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
  3. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Hirano Y, et al. Nature, 2005 Oct 27. PMID 16251969
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proteasome assembly chaperone 2
Names
proteasome (prosome, macropain) assembly chaperone 2
tumor necrosis factor superfamily, member 5-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106138.2 → NP_001099608.2  proteasome assembly chaperone 2

    Status: VALIDATED

    Source sequence(s)
    BM387084, CB798672, DV720222
    UniProtKB/TrEMBL
    A0A8I6G3H9, D3ZAQ4
    Conserved Domains (1) summary
    pfam09754
    Location:17 → 123
    PAC2; PAC2 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    63478620..63493193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277192.1 → XP_063133262.1  proteasome assembly chaperone 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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