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LGALS13 galectin 13 [ Homo sapiens (human) ]

Gene ID: 29124, updated on 11-Apr-2024

Summary

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Official Symbol
LGALS13provided by HGNC
Official Full Name
galectin 13provided by HGNC
Primary source
HGNC:HGNC:15449
See related
Ensembl:ENSG00000105198 MIM:608717; AllianceGenome:HGNC:15449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP13; GAL13; PLAC8
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 6.7) See more
Orthologs
all
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Genomic context

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See LGALS13 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39602524..39607474)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42406672..42411734)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40093164..40098114)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 25 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40086129-40087328 Neighboring gene MPRA-validated peak3478 silencer Neighboring gene ribosomal protein S29 pseudogene 26 Neighboring gene galectin 14 pseudogene Neighboring gene ribosomal protein S29 pseudogene 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease. Yi L, et al. COPD, 2023 Dec. PMID 36656660
  2. [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes]. Yi LL, et al. Zhonghua Yu Fang Yi Xue Za Zhi, 2022 Jun 6. PMID 35785865
  3. Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma. Yi L, et al. Clin Exp Allergy, 2021 Dec. PMID 34075657
  4. Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype. Vokalova L, et al. Front Immunol, 2020. PMID 32117288, Free PMC Article
  5. Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. Yang T, et al. Glycobiology, 2020 Jan 28. PMID 31584064

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
    Title: [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
  2. Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
    Title: Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
  3. Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
    Title: Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
  4. Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
    Title: Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
  5. PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
    Title: PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
  6. [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
    Title: [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
  7. Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
    Title: Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
  8. Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
    Title: Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
  9. Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
    Title: Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
  10. These results indicate that Gal-13 is not a normal galectin, which could not bind to beta-galactosides. Lastly, the distribution of EGFP-tagged wild-type Gal-13 and its variants in HeLa cells showed that they are concentrated in the nucleus and could be co-localized within filamentary materials, possibly actin.
    Title: Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
galactoside-binding soluble lectin 13
Names
beta-galactoside-binding lectin
gal-13
lectin, galactoside-binding, soluble, 13
placental protein 13
placental tissue protein 13
NP_037400.1
XP_011525176.2
XP_024307242.1
XP_054176728.1
XP_054176729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013268.3 → NP_037400.1  galactoside-binding soluble lectin 13

    See identical proteins and their annotated locations for NP_037400.1

    Status: REVIEWED

    Source sequence(s)
    AC005205
    Consensus CDS
    CCDS33024.1
    UniProtKB/Swiss-Prot
    C5HZ15, Q9UHV8
    Related
    ENSP00000221797.3, ENST00000221797.5
    Conserved Domains (1) summary
    smart00908
    Location:11 → 135
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39602524..39607474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451474.2 → XP_024307242.1  galactoside-binding soluble lectin 13 isoform X2

    Conserved Domains (1) summary
    smart00908
    Location:42 → 166
    Gal-bind_lectin; Galactoside-binding lectin

  2. XM_011526874.3 → XP_011525176.2  galactoside-binding soluble lectin 13 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42406672..42411734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320754.1 → XP_054176729.1  galactoside-binding soluble lectin 13 isoform X2

  2. XM_054320753.1 → XP_054176728.1  galactoside-binding soluble lectin 13 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHV8.1 GenPept UniProtKB/Swiss-Prot:Q9UHV8

Gene LinkOut

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