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B3galnt2 beta-1,3-N-acetylgalactosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291212, updated on 10-Oct-2024

Summary

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Official Symbol
B3galnt2provided by RGD
Official Full Name
beta-1,3-N-acetylgalactosaminyltransferase 2provided by RGD
Primary source
RGD:1306946
See related
EnsemblRapid:ENSRNOG00000016855 AllianceGenome:RGD:1306946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306946
Summary
Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A11. Orthologous to human B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 219.4), Heart (RPKM 174.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B3galnt2 in Genome Data Viewer
Location:
17q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (56030409..56072952, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (51334921..51377469, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (54027859..54070399, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 4B Neighboring gene geranylgeranyl diphosphate synthase 1 Neighboring gene tubulin folding cofactor E Neighboring gene ribosomal protein S19 like 4 Neighboring gene uncharacterized LOC134482723 Neighboring gene kinesin family member 5B Neighboring gene Rho GTPase activating protein 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in B3GALNT2 cause congenital muscular dystrophy and hypoglycosylation of α-dystroglycan. Stevens E, et al. Am J Hum Genet, 2013 Mar 7. PMID 23453667, Free PMC Article
  2. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Names
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
NP_001138323.1
XP_006254069.1
XP_006254070.1
XP_008769923.1
XP_038951453.1
XP_063132272.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144851.2 → NP_001138323.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

    See identical proteins and their annotated locations for NP_001138323.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2K550, A6K9D8, D3Z9C4
    Related
    ENSRNOP00000022924.5, ENSRNOT00000022924.8
    Conserved Domains (1) summary
    cl21608
    Location:309 → 459
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    56030409..56072952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254007.5 → XP_006254069.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K550, A0A8I6GEP1
    Related
    ENSRNOP00000086193.1, ENSRNOT00000105211.2
    Conserved Domains (1) summary
    cl21608
    Location:277 → 427
    Galactosyl_T; Galactosyltransferase

  2. XM_008771701.4 → XP_008769923.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K550
    Conserved Domains (1) summary
    cl21608
    Location:308 → 458
    Galactosyl_T; Galactosyltransferase

  3. XM_063276202.1 → XP_063132272.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X4

  4. XM_006254008.4 → XP_006254070.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X3

    See identical proteins and their annotated locations for XP_006254070.1

    UniProtKB/TrEMBL
    A0A0G2K550, A0A8I6GHC5
    Conserved Domains (1) summary
    cl21608
    Location:261 → 411
    Galactosyl_T; Galactosyltransferase

  5. XM_039095525.2 → XP_038951453.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K550, A0A8I6GHC5
    Related
    ENSRNOP00000088702.1, ENSRNOT00000117768.2
    Conserved Domains (1) summary
    cl21608
    Location:261 → 411
    Galactosyl_T; Galactosyltransferase

RNA

  1. XR_361036.5 RNA Sequence

  2. XR_005495256.2 RNA Sequence

  3. XR_010058837.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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