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Ggps1 geranylgeranyl diphosphate synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291211, updated on 2-Nov-2024

Summary

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Official Symbol
Ggps1provided by RGD
Official Full Name
geranylgeranyl diphosphate synthase 1provided by RGD
Primary source
RGD:1359680
See related
EnsemblRapid:ENSRNOG00000016767 AllianceGenome:RGD:1359680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crlf3; rGGPS1a; rGGPS1a1; rGGPS1a2; rGGPS1a3
Summary
Predicted to enable farnesyltranstransferase activity; geranyltranstransferase activity; and identical protein binding activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 61.4), Spleen (RPKM 59.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggps1 in Genome Data Viewer
Location:
17q12.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (55958750..55982762)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (51263262..51282471)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (53956185..53971039)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene Y-box-binding protein 1-like Neighboring gene AT-rich interaction domain 4B Neighboring gene tubulin folding cofactor E Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene ribosomal protein S19 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. Matsumura Y, et al. J Biochem, 2007 Oct. PMID 17846065
  2. Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level. Matsumura Y, et al. J Biochem, 2004 Sep. PMID 15598886
  3. Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. Ericsson J, et al. J Lipid Res, 1998 Sep. PMID 9741684
  4. Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. Kainou T, et al. Biochim Biophys Acta, 1999 Mar 25. PMID 10101267
  5. Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi T, et al. J Biol Chem, 1999 Feb 26. PMID 10026212

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KMFTEENE fragment residing on the carboxyl-terminal sequence of geranylgeranyl diphosphate synthase stabilizes the active region involved in the substrate binding and catalysis.
    Title: The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis.
  2. expression level of rat active GGPS is regulated through the splicing of intron 4b of its gene
    Title: Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables farnesyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables farnesyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables farnesyltranstransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables geranyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in farnesyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in geranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in geranylgeranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isoprenoid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
geranylgeranyl pyrophosphate synthase
Names
(2E,6E)-farnesyl diphosphate synthase
GGPP synthase
GGPP synthetase
GGPPSase
dimethylallyltranstransferase
farnesyl diphosphate synthase
farnesyltranstransferase
geranylgeranyl pyrophosphate synthetase
geranyltranstransferase
NP_001007627.1
XP_008769921.1
XP_038951449.1
XP_038951450.1
XP_038951451.1
XP_063132269.1
XP_063132270.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007626.4 → NP_001007627.1  geranylgeranyl pyrophosphate synthase

    See identical proteins and their annotated locations for NP_001007627.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q6F596
    Related
    ENSRNOP00000094969.2, ENSRNOT00000095806.2
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    55958750..55982762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276199.1 → XP_063132269.1  geranylgeranyl pyrophosphate synthase isoform X2

  2. XM_063276200.1 → XP_063132270.1  geranylgeranyl pyrophosphate synthase isoform X4

    UniProtKB/TrEMBL
    A6K9C8

  3. XM_039095523.2 → XP_038951451.1  geranylgeranyl pyrophosphate synthase isoform X3

    Conserved Domains (1) summary
    pfam00348
    Location:9 → 232
    polyprenyl_synt; Polyprenyl synthetase

  4. XM_008771699.3 → XP_008769921.1  geranylgeranyl pyrophosphate synthase isoform X5

    See identical proteins and their annotated locations for XP_008769921.1

    Conserved Domains (1) summary
    pfam00348
    Location:1 → 197
    polyprenyl_synt; Polyprenyl synthetase

  5. XM_039095522.2 → XP_038951450.1  geranylgeranyl pyrophosphate synthase isoform X1

    UniProtKB/Swiss-Prot
    Q6F596
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  6. XM_039095521.2 → XP_038951449.1  geranylgeranyl pyrophosphate synthase isoform X1

    UniProtKB/Swiss-Prot
    Q6F596
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6F596.1 GenPept UniProtKB/Swiss-Prot:Q6F596

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