Epdr1 ependymin related 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epdr1provided by RGD
Official Full Name: ependymin related 1provided by RGD
Primary source: RGD:1359161
See related: EnsemblRapid:ENSRNOG00000060141 AllianceGenome:RGD:1359161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epdr2; MERP2
Summary: Predicted to enable ganglioside GM1 binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in myofibroblast contraction. Predicted to be located in extracellular region. Predicted to be active in lysosome. Orthologous to human EPDR1 (ependymin related 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 250.5), Heart (RPKM 235.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (50029591..50054254)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (45333932..45358597)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (47397558..47422183)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel density shift method was used to demonstrate that EPDR resides in the lysosome.
Title: Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.

Submit: New GeneRIF Correction

General gene information

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Markers

D17Wox29 (e-PCR)
- UniSTS:518501

RH128255 (e-PCR)
- UniSTS:211563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GM1 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in myofibroblast contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mammalian ependymin-related protein 1

Names: MERP-1; ependymin related protein 1; upregulated in colorectal cancer gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.