Fastkd3 FAST kinase domains 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fastkd3provided by RGD
Official Full Name: FAST kinase domains 3provided by RGD
Primary source: RGD:1309729
See related: EnsemblRapid:ENSRNOG00000027422 AllianceGenome:RGD:1309729
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309729
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing; mitochondrial cytochrome c oxidase assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTKD3 (FAST kinase domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 59.6), Kidney (RPKM 56.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (36686727..36695376, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (34858342..34866988, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (37734400..37742932, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial mRNA stability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FAST kinase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082574.1 → NP_001076043.1 FAST kinase domain-containing protein 3, mitochondrial precursor

See identical proteins and their annotated locations for NP_001076043.1

Status: PROVISIONAL

Source sequence(s)

BC079475, CK359441

UniProtKB/Swiss-Prot

Q68FN9

UniProtKB/TrEMBL

A6JV27

Related

ENSRNOP00000029498.4, ENSRNOT00000034410.8

Conserved Domains (3) summary

smart00952
Location:589 → 646

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:405 → 473

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:489 → 575

FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

36686727..36695376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227811.3 → XP_006227873.1 FAST kinase domain-containing protein 3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006227873.1

UniProtKB/Swiss-Prot

Q68FN9

UniProtKB/TrEMBL

A6JV27

Conserved Domains (3) summary

smart00952
Location:589 → 646

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:405 → 473

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:489 → 575

FAST_2; FAST kinase-like protein, subdomain 2
XM_006227809.4 → XP_006227871.1 FAST kinase domain-containing protein 3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006227871.1

UniProtKB/Swiss-Prot

Q68FN9

UniProtKB/TrEMBL

A6JV27

Conserved Domains (3) summary

smart00952
Location:589 → 646

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:405 → 473

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:489 → 575

FAST_2; FAST kinase-like protein, subdomain 2
XM_039102861.2 → XP_038958789.1 FAST kinase domain-containing protein 3, mitochondrial isoform X3

UniProtKB/TrEMBL

A6JV28

Conserved Domains (2) summary

smart00952
Location:120 → 177

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam08368
Location:18 → 106

FAST_2; FAST kinase-like protein, subdomain 2
XM_063282704.1 → XP_063138774.1 FAST kinase domain-containing protein 3, mitochondrial isoform X2