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Cdc16 cell division cycle 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290875, updated on 28-Oct-2024

Summary

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Official Symbol
Cdc16provided by RGD
Official Full Name
cell division cycle 16provided by RGD
Primary source
RGD:1305076
See related
EnsemblRapid:ENSRNOG00000017536 AllianceGenome:RGD:1305076
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in centrosome; mitotic spindle; and nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 169.0), Kidney (RPKM 128.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc16 in Genome Data Viewer
Location:
16q12.5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82475234..82498797, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (75773026..75796586, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81493355..81516493)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Neighboring gene UPF3A, regulator of nonsense mediated mRNA decay Neighboring gene uncharacterized LOC120097557 Neighboring gene CFAP97 domain containing 2 Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC120097558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich S, et al. Cell, 1995 Apr 21. PMID 7736578
  2. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
  3. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle protein 16 homolog
Names
cell division cycle 16 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024744.1 → NP_001019915.1  cell division cycle protein 16 homolog

    See identical proteins and their annotated locations for NP_001019915.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097498
    UniProtKB/TrEMBL
    A0A0G2JT88, Q4V884
    Related
    ENSRNOP00000023736.6, ENSRNOT00000023736.9
    Conserved Domains (5) summary
    COG3063
    Location:371 → 511
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    TIGR02917
    Location:134 → 502
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:447 → 473
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:447 → 511
    TPR_12; Tetratricopeptide repeat
    pfam12895
    Location:15 → 94
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    82475234..82498797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094410.2 → XP_038950338.1  cell division cycle protein 16 homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT88
    Conserved Domains (4) summary
    COG3063
    Location:277 → 417
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    TIGR02917
    Location:40 → 408
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:353 → 379
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353 → 417
    TPR_12; Tetratricopeptide repeat

  2. XM_063275254.1 → XP_063131324.1  cell division cycle protein 16 homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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