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Mvb12a multivesicular body subunit 12A [ Rattus norvegicus (Norway rat) ]

Gene ID: 290635, updated on 2-Nov-2024

Summary

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Official Symbol
Mvb12aprovided by RGD
Official Full Name
multivesicular body subunit 12Aprovided by RGD
Primary source
RGD:735220
See related
EnsemblRapid:ENSRNOG00000017949 AllianceGenome:RGD:735220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam125a
Summary
Predicted to enable lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in centrosome; intracellular membrane-bounded organelle; and vesicle. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to human MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 140.1), Lung (RPKM 122.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mvb12a in Genome Data Viewer
Location:
16p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18286231..18291096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18252227..18257111)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19973611..19978479)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 39 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 1 Neighboring gene transmembrane protein 221 Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 member 1 Neighboring gene 6-phosphogluconolactonase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Boura E, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22232651, Free PMC Article
  2. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Tsunematsu T, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654576
  3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72581

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in viral budding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral budding IEA
Inferred from Electronic Annotation
more info
  
involved_in virus maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in virus maturation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
multivesicular body subunit 12A
Names
ESCRT-I complex subunit MVB12A
family with sequence similarity 125, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199375.1 → NP_955407.1  multivesicular body subunit 12A

    See identical proteins and their annotated locations for NP_955407.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061799
    UniProtKB/Swiss-Prot
    Q6P777
    UniProtKB/TrEMBL
    A0A8L2UJY5, A6K9V5
    Related
    ENSRNOP00000094107.2, ENSRNOT00000110078.2
    Conserved Domains (1) summary
    pfam10240
    Location:8 → 259
    DUF2464; Multivesicular body subunit 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18286231..18291096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275153.1 → XP_063131223.1  multivesicular body subunit 12A isoform X4

  2. XM_006252860.5 → XP_006252922.1  multivesicular body subunit 12A isoform X1

    UniProtKB/TrEMBL
    A6K9V7
    Conserved Domains (1) summary
    pfam10240
    Location:8 → 212
    DUF2464; Protein of unknown function (DUF2464)

  3. XM_063275151.1 → XP_063131221.1  multivesicular body subunit 12A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIU5

  4. XM_063275152.1 → XP_063131222.1  multivesicular body subunit 12A isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P777.1 GenPept UniProtKB/Swiss-Prot:Q6P777

Gene LinkOut

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