U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Babam1 BRISC and BRCA1 A complex member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290631, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Babam1provided by RGD
Official Full Name
BRISC and BRCA1 A complex member 1provided by RGD
Primary source
RGD:1359516
See related
EnsemblRapid:ENSRNOG00000017071 AllianceGenome:RGD:1359516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Merit40
Summary
Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and protein K63-linked deubiquitination. Predicted to act upstream of or within hematopoietic stem cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 127.8), Thymus (RPKM 123.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Babam1 in Genome Data Viewer
Location:
16p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18102885..18108916)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18068830..18074938)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19792720..19798886)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group F, member 6 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene uncharacterized LOC134482465 Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene RB binding protein 7, chromatin remodeling factor, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Rozenova K, et al. Blood, 2015 Mar 12. PMID 25636339, Free PMC Article
  2. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Shao G, et al. Genes Dev, 2009 Mar 15. PMID 19261746, Free PMC Article
  3. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. Cooper EM, et al. EMBO J, 2009 Mar 18. PMID 19214193, Free PMC Article
  4. MERIT40 facilitates BRCA1 localization and DNA damage repair. Feng L, et al. Genes Dev, 2009 Mar 15. PMID 19261748, Free PMC Article
  5. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Wang B, et al. Genes Dev, 2009 Mar 15. PMID 19261749, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94542

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRCA1-A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of BRISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRISC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
BRISC and BRCA1-A complex member 1
Names
BRCA1-A complex subunit MERIT40
mediator of RAP80 interactions and targeting subunit of 40 kDa
new component of the BRCA1-A complex

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006964.1 → NP_001006965.1  BRISC and BRCA1-A complex member 1

    See identical proteins and their annotated locations for NP_001006965.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083685
    UniProtKB/Swiss-Prot
    Q5XIJ6
    UniProtKB/TrEMBL
    A6K9T3
    Related
    ENSRNOP00000022938.3, ENSRNOT00000022938.7
    Conserved Domains (2) summary
    PRK07003
    Location:24 → 93
    PRK07003; DNA polymerase III subunit gamma/tau
    cd21502
    Location:96 → 316
    vWA_BABAM1; Von-Willebrand factor A (vWA) domain found in BRISC and BRCA1-A complex member 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18102885..18108916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094296.2 → XP_038950224.1  BRISC and BRCA1-A complex member 1 isoform X1

    UniProtKB/TrEMBL
    A6K9T2
    Conserved Domains (1) summary
    cd21502
    Location:96 → 196
    vWA_BABAM1; Von-Willebrand factor A (vWA) domain found in BRISC and BRCA1-A complex member 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIJ6.1 GenPept UniProtKB/Swiss-Prot:Q5XIJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous