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Chdh choline dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290551, updated on 2-Nov-2024

Summary

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Official Symbol
Chdhprovided by RGD
Official Full Name
choline dehydrogenaseprovided by RGD
Primary source
RGD:735166
See related
EnsemblRapid:ENSRNOG00000015859 AllianceGenome:RGD:735166
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CDH; CHD
Summary
Enables choline dehydrogenase activity. Predicted to be involved in glycine betaine biosynthetic process from choline. Located in mitochondrial inner membrane. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 288.5), Liver (RPKM 282.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chdh in Genome Data Viewer
Location:
16p16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (5199738..5232067)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (5194269..5225541)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6078083..6109386)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene selenoprotein K Neighboring gene actin related protein 8 Neighboring gene interleukin 17 receptor B Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene uncharacterized LOC108348454 Neighboring gene uncharacterized LOC120097386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. Slow S, et al. J Nutr, 2006 Sep. PMID 16920841
  2. Functional expression and processing of rat choline dehydrogenase precursor. Huang S, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951056
  3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. kidney betaine-homocysteine methyltransferase (BHMT) and liver Choline dehydrogenase (CHDH) expression were refractory to dietary choline and methionine
    Title: Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC93763

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables choline dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine betaine biosynthetic process from choline IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
choline dehydrogenase, mitochondrial
NP_942026.1
XP_006252641.1
XP_008769206.1
XP_063131200.1
XP_063131201.1
XP_063131202.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198731.3 → NP_942026.1  choline dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_942026.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q6UPE0
    Related
    ENSRNOP00000021407.4, ENSRNOT00000021407.6
    Conserved Domains (4) summary
    PRK02106
    Location:45 → 591
    PRK02106; choline dehydrogenase; Validated
    pfam00732
    Location:121 → 344
    GMC_oxred_N; GMC oxidoreductase
    pfam05199
    Location:435 → 572
    GMC_oxred_C; GMC oxidoreductase
    cl21454
    Location:49 → 151
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    5199738..5232067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275132.1 → XP_063131202.1  choline dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UPE0

  2. XM_063275130.1 → XP_063131200.1  choline dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UPE0

  3. XM_006252579.5 → XP_006252641.1  choline dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006252641.1

    UniProtKB/Swiss-Prot
    Q6UPE0
    Related
    ENSRNOP00000111940.1, ENSRNOT00000153834.1
    Conserved Domains (4) summary
    PRK02106
    Location:45 → 591
    PRK02106; choline dehydrogenase; Validated
    pfam00732
    Location:121 → 344
    GMC_oxred_N; GMC oxidoreductase
    pfam05199
    Location:435 → 572
    GMC_oxred_C; GMC oxidoreductase
    cl21454
    Location:49 → 151
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_063275131.1 → XP_063131201.1  choline dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UPE0

  5. XM_008770984.4 → XP_008769206.1  choline dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008769206.1

    UniProtKB/Swiss-Prot
    Q6UPE0
    Conserved Domains (4) summary
    PRK02106
    Location:45 → 591
    PRK02106; choline dehydrogenase; Validated
    pfam00732
    Location:121 → 344
    GMC_oxred_N; GMC oxidoreductase
    pfam05199
    Location:435 → 572
    GMC_oxred_C; GMC oxidoreductase
    cl21454
    Location:49 → 151
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UPE0.1 GenPept UniProtKB/Swiss-Prot:Q6UPE0

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