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Ugp2 UDP-glucose pyrophosphorylase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289827, updated on 18-Sep-2024

Summary

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Official Symbol
Ugp2provided by RGD
Official Full Name
UDP-glucose pyrophosphorylase 2provided by RGD
Primary source
RGD:1310210
See related
EnsemblRapid:ENSRNOG00000008079 AllianceGenome:RGD:1310210
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables UTP:glucose-1-phosphate uridylyltransferase activity; glucose binding activity; and pyrimidine ribonucleotide binding activity. Involved in UDP-glucose metabolic process and glucose 1-phosphate metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1998.6), Liver (RPKM 1031.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ugp2 in Genome Data Viewer
Location:
14q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (99657637..99698573, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (95456330..95497483, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (106208174..106249322, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene pellino E3 ubiquitin protein ligase 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene VPS54 subunit of GARP complex Neighboring gene uncharacterized LOC134481874 Neighboring gene large ribosomal subunit protein eL21-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Control of glucuronidation during hypoxia. Limitation by UDP-glucose pyrophosphorylase. Aw TY, et al. Biochem J, 1984 May 1. PMID 6331395, Free PMC Article
  2. The concentration and control of cytoplasmic free inorganic pyrophosphate in rat liver in vivo. Guynn RW, et al. Biochem J, 1974 Jun. PMID 4374936, Free PMC Article
  3. Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liver. Knop JK, et al. J Biol Chem, 1970 May 25. PMID 5427280
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-glucose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP-monosaccharide-1-phosphate uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine ribonucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-glucuronate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose 1-phosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
NP_001019914.1
XP_006251600.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024743.1 → NP_001019914.1  UTP--glucose-1-phosphate uridylyltransferase

    See identical proteins and their annotated locations for NP_001019914.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097369
    UniProtKB/TrEMBL
    A0A0G2K542, A0A9K3Y8H8, F1LQ84, Q4V8I9
    Related
    ENSRNOP00000063786.2, ENSRNOT00000067668.5
    Conserved Domains (1) summary
    pfam01704
    Location:57 → 473
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    99657637..99698573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251538.3 → XP_006251600.1  UTP--glucose-1-phosphate uridylyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K542, A0A8I6G7V9
    Related
    ENSRNOP00000073284.2, ENSRNOT00000081245.3
    Conserved Domains (1) summary
    pfam01704
    Location:46 → 462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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