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Myo1g myosin IG [ Rattus norvegicus (Norway rat) ]

Gene ID: 289785, updated on 17-Aug-2024

Summary

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Official Symbol
Myo1gprovided by RGD
Official Full Name
myosin IGprovided by RGD
Primary source
RGD:1306016
See related
EnsemblRapid:ENSRNOG00000059140 AllianceGenome:RGD:1306016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Fc-gamma receptor signaling pathway involved in phagocytosis and T cell mediated immunity. Predicted to act upstream of or within several processes, including T cell meandering migration; cell gliding; and phagocytosis. Predicted to be located in several cellular components, including lamellipodium; microvillus; and phagocytic cup. Predicted to be part of myosin complex. Orthologous to human MYO1G (myosin IG). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 241.4), Thymus (RPKM 220.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myo1g in Genome Data Viewer
Location:
14q21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85600619..85615760, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81386701..81401843, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86781243..86796393, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L13-like Neighboring gene uncharacterized LOC103693157 Neighboring gene uncharacterized LOC102547700 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene CCM2 scaffold protein Neighboring gene uncharacterized protein C11orf98 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes. Maravillas-Montero JL, et al. Eur J Immunol, 2014 Mar. PMID 24310084
  2. The motor protein myosin 1G functions in FcγR-mediated phagocytosis. Dart AE, et al. J Cell Sci, 2012 Dec 15. PMID 23038771
  3. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Gérard A, et al. Cell, 2014 Jul 31. PMID 25083865, Free PMC Article
  4. Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. Olety B, et al. FEBS Lett, 2010 Feb 5. PMID 19968988
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109586

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell meandering migration ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell gliding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
unconventional myosin-Ig
Names
myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134843.1 → NP_001128315.1  unconventional myosin-Ig

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6IKU7
    Conserved Domains (3) summary
    smart00242
    Location:4 → 703
    MYSc; Myosin. Large ATPases
    cd01378
    Location:23 → 691
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:812 → 1002
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    85600619..85615760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251218.5 → XP_006251280.1  unconventional myosin-Ig isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6E3, A6IKU7
    Related
    ENSRNOP00000073777.1, ENSRNOT00000092021.3
    Conserved Domains (3) summary
    smart00242
    Location:4 → 706
    MYSc; Myosin. Large ATPases
    cd01378
    Location:23 → 694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:815 → 1005
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  2. XM_006251221.5 → XP_006251283.1  unconventional myosin-Ig isoform X2

    See identical proteins and their annotated locations for XP_006251283.1

    Conserved Domains (2) summary
    cl22853
    Location:49 → 496
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:617 → 807
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  3. XM_006251223.4 → XP_006251285.1  unconventional myosin-Ig isoform X2

    See identical proteins and their annotated locations for XP_006251285.1

    Conserved Domains (2) summary
    cl22853
    Location:49 → 496
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:617 → 807
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009634.1: Suppressed sequence

    Description
    NM_001009634.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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