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Ube2k ubiquitin-conjugating enzyme E2K [ Rattus norvegicus (Norway rat) ]

Gene ID: 289623, updated on 18-Sep-2024

Summary

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Official Symbol
Ube2kprovided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2Kprovided by RGD
Primary source
RGD:1311626
See related
EnsemblRapid:ENSRNOG00000027088 AllianceGenome:RGD:1311626
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lig; Hip2; Hypg; E2-25k
Summary
Predicted to enable ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in cytoplasm and filopodium tip. Predicted to be active in nucleus. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 175.1), Kidney (RPKM 123.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2k in Genome Data Viewer
Location:
14p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43011681..43077825, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42658016..42718899, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44289247..44348691, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor A Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14 like 2 Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14 Neighboring gene UDP-glucose 6-dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. Song S, et al. J Cell Biol, 2008 Aug 25. PMID 18710920, Free PMC Article
  2. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Wassler MJ, et al. Stem Cells, 2008 Aug. PMID 18511602
  3. Expression of TMEM16 paralogs during murine embryogenesis. Rock JR, et al. Dev Dyn, 2008 Sep. PMID 18729231
  4. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Christensen DE, et al. Nat Struct Mol Biol, 2007 Oct. PMID 17873885
  5. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Nathan JA, et al. Traffic, 2008 Jul. PMID 18410486, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in free ubiquitin chain polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 K
Names
huntingtin interacting protein 2
ubiquitin-conjugating enzyme E2-25K
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
NP_001099476.1
XP_038947644.1
XP_038947645.1
XP_063128995.1
XP_063128996.1
XP_063128997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106006.1 → NP_001099476.1  ubiquitin-conjugating enzyme E2 K

    See identical proteins and their annotated locations for NP_001099476.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473981
    UniProtKB/TrEMBL
    A0A8I6AV01, A6JDD4
    Conserved Domains (2) summary
    cd00195
    Location:6 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cd14390
    Location:163 → 200
    UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43011681..43077825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091716.2 → XP_038947644.1  ubiquitin-conjugating enzyme E2 K isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2L8, A0A8I6AV01
    Related
    ENSRNOP00000104117.1, ENSRNOT00000170213.1
    Conserved Domains (2) summary
    cd00195
    Location:35 → 159
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cd14390
    Location:173 → 210
    UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

  2. XM_039091717.2 → XP_038947645.1  ubiquitin-conjugating enzyme E2 K isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMB3, A0A8I6AV01, A6JDD3
    Related
    ENSRNOP00000079243.1, ENSRNOT00000105695.2
    Conserved Domains (2) summary
    smart00212
    Location:22 → 103
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    cl21463
    Location:112 → 149
    UBA_like_SF; UBA domain-like superfamily

  3. XM_063272925.1 → XP_063128995.1  ubiquitin-conjugating enzyme E2 K isoform X3

    UniProtKB/TrEMBL
    A6JDD5

  4. XM_063272926.1 → XP_063128996.1  ubiquitin-conjugating enzyme E2 K isoform X3

    UniProtKB/TrEMBL
    A6JDD5

  5. XM_063272927.1 → XP_063128997.1  ubiquitin-conjugating enzyme E2 K isoform X3

    UniProtKB/TrEMBL
    A6JDD5
Nucleotide Protein Strain
Heading Accession and Version

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