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Inava innate immunity activator [ Rattus norvegicus (Norway rat) ]

Gene ID: 289399, updated on 2-Nov-2024

Summary

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Official Symbol
Inavaprovided by RGD
Official Full Name
innate immunity activatorprovided by RGD
Primary source
RGD:1311892
See related
EnsemblRapid:ENSRNOG00000025948 AllianceGenome:RGD:1311892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311892
Summary
Predicted to be involved in several processes, including intestinal epithelial structure maintenance; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm and nuclear body. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 21.1), Testes (RPKM 5.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Inava in Genome Data Viewer
Location:
13q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50218149..50238430, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47666446..47687383, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53088438..53108713, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene mitochondrial ribosomal protein L42 like 1 Neighboring gene uncharacterized LOC120096257 Neighboring gene uncharacterized LOC120096220 Neighboring gene G protein-coupled receptor 25 Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene uncharacterized LOC134481565

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. Yan J, et al. J Clin Invest, 2017 Jun 1. PMID 28436939, Free PMC Article
  2. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Mohanan V, et al. Science, 2018 Mar 9. PMID 29420262, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in adherens junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adherens junction maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal epithelial structure maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptidoglycan ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
innate immunity activator protein
Names
uncharacterized protein C1orf106 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134502.2 → NP_001127974.1  innate immunity activator protein isoform 2

    See identical proteins and their annotated locations for NP_001127974.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICI2, D3ZL84
    Conserved Domains (1) summary
    pfam11819
    Location:107 → 230
    DUF3338; Domain of unknown function (DUF3338)

  2. NM_001434183.1 → NP_001421112.1  innate immunity activator protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001434195.1 → NP_001421124.1  innate immunity activator protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50218149..50238430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249920.5 → XP_006249982.1  innate immunity activator protein isoform X1

    Related
    ENSRNOP00000034553.5, ENSRNOT00000035404.7
    Conserved Domains (1) summary
    pfam11819
    Location:108 → 231
    DUF3338; Domain of unknown function (DUF3338)

  2. XM_006249922.5 → XP_006249984.1  innate immunity activator protein isoform X2

    Conserved Domains (1) summary
    pfam11819
    Location:8 → 131
    DUF3338; Domain of unknown function (DUF3338)
Nucleotide Protein Strain
Heading Accession and Version

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