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Rps6kc1 ribosomal protein S6 kinase C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289342, updated on 14-Nov-2024

Summary

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Official Symbol
Rps6kc1provided by RGD
Official Full Name
ribosomal protein S6 kinase C1provided by RGD
Primary source
RGD:1306578
See related
EnsemblRapid:ENSRNOG00000003767 AllianceGenome:RGD:1306578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and phosphatidylinositol binding activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in endosome and lysosome. Predicted to be active in early endosome and postsynaptic density. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 57.2), Thymus (RPKM 34.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rps6kc1 in Genome Data Viewer
Location:
13q27
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (104877296..105021490, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102346160..102491000, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109338761..109589209, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096349 Neighboring gene uncharacterized LOC134481636 Neighboring gene uncharacterized LOC134481611 Neighboring gene H3.3 histone B like 1 Neighboring gene angel homolog 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Liu L, et al. Mol Cells, 2005 Feb 28. PMID 15750338
  2. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase delta-1
Names
ribosomal protein S6 kinase, 52kDa, polypeptide 1
ribosomal protein S6 kinase, polypeptide 1
ribosomal protein S6 kinase, polypeptide C1
NP_001402718.1
NP_001402719.1
XP_008768052.1
XP_008768054.1
XP_038946506.1
XP_063128247.1
XP_063128248.1
XP_063128249.1
XP_063128250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415789.1 → NP_001402718.1  ribosomal protein S6 kinase delta-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  2. NM_001415790.1 → NP_001402719.1  ribosomal protein S6 kinase delta-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2KB60
    Related
    ENSRNOP00000075665.1, ENSRNOT00000087305.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    104877296..105021490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769830.2 → XP_008768052.1  ribosomal protein S6 kinase delta-1 isoform X2

    UniProtKB/TrEMBL
    A6JGX5, D3Z991
    Conserved Domains (5) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    smart00220
    Location:747 → 915
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05576
    Location:738 → 915
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl00299
    Location:140 → 185
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:214 → 300
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039090578.2 → XP_038946506.1  ribosomal protein S6 kinase delta-1 isoform X1

    UniProtKB/TrEMBL
    A6JGX5, D3Z991
    Related
    ENSRNOP00000085010.2, ENSRNOT00000110098.2
    Conserved Domains (4) summary
    cd07287
    Location:11 → 128
    PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
    cd02677
    Location:237 → 305
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:827 → 1004
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:300 → 389
    PKc_like; Protein Kinases, catalytic domain

  3. XM_063272177.1 → XP_063128247.1  ribosomal protein S6 kinase delta-1 isoform X3

  4. XM_063272179.1 → XP_063128249.1  ribosomal protein S6 kinase delta-1 isoform X3

  5. XM_063272178.1 → XP_063128248.1  ribosomal protein S6 kinase delta-1 isoform X3

  6. XM_063272180.1 → XP_063128250.1  ribosomal protein S6 kinase delta-1 isoform X3

  7. XM_008769832.4 → XP_008768054.1  ribosomal protein S6 kinase delta-1 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:552 → 720
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05576
    Location:543 → 720
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    cl21453
    Location:32 → 105
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001840773.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105984.1: Suppressed sequence

    Description
    NM_001105984.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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