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Susd4 sushi domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289335, updated on 2-Nov-2024

Summary

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Official Symbol
Susd4provided by RGD
Official Full Name
sushi domain containing 4provided by RGD
Primary source
RGD:1564043
See related
EnsemblRapid:ENSRNOG00000003562 AllianceGenome:RGD:1564043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564043
Summary
Predicted to be involved in negative regulation of complement activation, alternative pathway; negative regulation of complement activation, classical pathway; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 112.1), Muscle (RPKM 8.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Susd4 in Genome Data Viewer
Location:
13q26
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96982867..97109419)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94455180..94577773)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101181932..101307912)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene coiled-coil domain containing 185 Neighboring gene uncharacterized LOC120096332 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase. Holmquist E, et al. FASEB J, 2013 Jun. PMID 23482636
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sushi domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105982.1 → NP_001099452.1  sushi domain-containing protein 4

    See identical proteins and their annotated locations for NP_001099452.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A0A8I6GG96, A6JGM6, D4A231
    Related
    ENSRNOP00000107157.1, ENSRNOT00000160532.1
    Conserved Domains (2) summary
    PHA02639
    Location:30 → 238
    PHA02639; EEV host range protein; Provisional
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    96982867..97109419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272171.1 → XP_063128241.1  sushi domain-containing protein 4 isoform X1

  2. XM_039090566.2 → XP_038946494.1  sushi domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GG96, A6JGM6, D4A231
    Related
    ENSRNOP00000045726.3, ENSRNOT00000052407.7
    Conserved Domains (2) summary
    PHA02639
    Location:30 → 238
    PHA02639; EEV host range protein; Provisional
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

  3. XM_063272172.1 → XP_063128242.1  sushi domain-containing protein 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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