Ntmt2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntmt2provided by RGD
Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by RGD
Primary source: RGD:1564106
See related: EnsemblRapid:ENSRNOG00000025415 AllianceGenome:RGD:1564106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NTM1B; Mettl11b; RGD1564106
Summary: Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 75.3), Muscle (RPKM 71.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (78585663..78627144, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76050683..76093972, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (81987877..82027781, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-terminal protein N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-terminal protein N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-terminal protein N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid methylation	IEA Inferred from Electronic Annotation more info
involved_in N-terminal protein amino acid methylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-terminal Xaa-Pro-Lys N-methyltransferase 2

Names: X-Pro-Lys N-terminal protein methyltransferase 1B; alpha N-terminal protein methyltransferase 1B; methyltransferase like 11B; methyltransferase-like protein 11B

NP_001363789.1

EC 2.1.1.299

XP_038946415.1

EC 2.1.1.299

XP_038946416.1

EC 2.1.1.299

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376860.1 → NP_001363789.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

D3ZVR1

Related

ENSRNOP00000068028.1, ENSRNOT00000076404.4

Conserved Domains (1) summary

cl17173
Location:63 → 277

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

78585663..78627144 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090487.2 → XP_038946415.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

UniProtKB/Swiss-Prot

D3ZVR1

Conserved Domains (1) summary

cl17173
Location:63 → 277

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039090488.2 → XP_038946416.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X2

UniProtKB/TrEMBL

A0A0A0MP81, A6IDC3

Conserved Domains (1) summary

cl17173
Location:34 → 200

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...