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Cenpl centromere protein L [ Rattus norvegicus (Norway rat) ]

Gene ID: 289150, updated on 14-Nov-2024

Summary

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Official Symbol
Cenplprovided by RGD
Official Full Name
centromere protein Lprovided by RGD
Primary source
RGD:1311868
See related
EnsemblRapid:ENSRNOG00000038789 AllianceGenome:RGD:1311868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311868
Summary
Predicted to be located in chromosome and nucleus. Predicted to be part of inner kinetochore. Orthologous to human CENPL (centromere protein L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 110.6), Spleen (RPKM 88.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cenpl in Genome Data Viewer
Location:
13q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (75870479..75885466)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73337235..73352115)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (78886092..78901025)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Small nucleolar RNA SNORD81 Neighboring gene growth arrest specific 5 Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene ribosomal protein S10-like Neighboring gene kelch-like family member 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC125045

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centromere protein L
Names
CENP-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033061.2 → NP_001028233.2  centromere protein L isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
    Source sequence(s)
    BC079467
    UniProtKB/TrEMBL
    A0A0A6YYD9, A0A8L2QZG7
    Related
    ENSRNOP00000109606.1, ENSRNOT00000134960.1
    Conserved Domains (1) summary
    pfam13092
    Location:185 → 331
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  2. NM_001244761.1 → NP_001231690.1  centromere protein L isoform 2

    See identical proteins and their annotated locations for NP_001231690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC089893
    UniProtKB/Swiss-Prot
    Q0P5Q6, Q3ZAU7
    UniProtKB/TrEMBL
    A0A8L2QZG7, A6ID73
    Related
    ENSRNOP00000056033.3, ENSRNOT00000059266.5
    Conserved Domains (1) summary
    pfam13092
    Location:178 → 324
    CENP-L; Kinetochore complex Sim4 subunit Fta1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    75870479..75885466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250099.5 → XP_006250161.1  centromere protein L isoform X1

    UniProtKB/TrEMBL
    A0A8L2QZG7
    Related
    ENSRNOP00000100501.1, ENSRNOT00000129382.1
    Conserved Domains (1) summary
    pfam13092
    Location:185 → 329
    CENP-L; Kinetochore complex Sim4 subunit Fta1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZAU7.1 GenPept UniProtKB/Swiss-Prot:Q3ZAU7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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