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FKS1 FKS1 [ Nakaseomyces glabratus ]

Gene ID: 2888318, updated on 19-Jun-2024

Summary

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Gene symbol
FKS1
Gene description
FKS1
Locus tag
GVI51_G00891
See related
FungiDB:GVI51_G00891; VEuPathDB:GVI51_G00891
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Nakaseomyces glabratus (strain: ATCC 2001, nat-host: Homo sapiens, culture-collection: ATCC:2001, type-material: type material of Cryptococcus glabratus)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces
Old locus tag
CAGL0G01034g
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Genomic context

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See FKS1 in Genome Data Viewer
Location:
chromosome: G
Exon count:
1
Sequence:
Chromosome: G; NC_088957.1 (107061..112652)

Chromosome G - NC_088957.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene 60S ribosomal protein uL10 Neighboring gene GAS3 Neighboring gene 60S ribosomal protein uL24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_088957.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: Fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure. Arastehfar A, et al. Mycoses, 2020 Sep. PMID 32413170, Free PMC Article
  2. De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays. Xu Z, et al. Mol Microbiol, 2020 Jun. PMID 32068314
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: Fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure.
    Title: Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: Fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure.
Submit: New GeneRIF Correction

General gene information

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Homology

  • CAGL0G01034g
    Putative 1,3-beta-glucan synthase component; functionally redundant with Fks2p; 'hot spot' mutations in FKS1 confer resistance to echinocandins

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1,3-beta-D-glucan synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fungal-type cell wall polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of 1,3-beta-D-glucan synthase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
FKS1
XP_446406.1
  • CAGL0G01034g
    Putative 1,3-beta-glucan synthase component; functionally redundant with Fks2p; 'hot spot' mutations in FKS1 confer resistance to echinocandins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_088957.1 Reference assembly

    Range
    107061..112652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_446406.1 → XP_446406.1  FKS1 [Nakaseomyces glabratus]

    See identical proteins and their annotated locations for XP_446406.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    E2GKZ3, E2GKZ4, Q6FTN8
    Conserved Domains (2) summary
    pfam02364
    Location:794 → 1618
    Glucan_synthase; 1,3-beta-glucan synthase component
    pfam14288
    Location:286 → 395
    FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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