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Tfip11 tuftelin interacting protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288718, updated on 2-Nov-2024

Summary

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Official Symbol
Tfip11provided by RGD
Official Full Name
tuftelin interacting protein 11provided by RGD
Primary source
RGD:1311449
See related
EnsemblRapid:ENSRNOG00000000663 AllianceGenome:RGD:1311449
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in negative regulation of protein-containing complex assembly and spliceosomal complex disassembly. Predicted to be located in chromosome, telomeric region; extracellular matrix; and nuclear lumen. Predicted to be part of U2-type post-mRNA release spliceosomal complex and catalytic step 2 spliceosome. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 65.5), Thymus (RPKM 64.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tfip11 in Genome Data Viewer
Location:
12q16
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (49960025..49972257, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44299619..44311851, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50320820..50333052, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene SRR1 domain containing Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene crystallin, beta B1 Neighboring gene crystallin, beta A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Tannukit S, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19857462, Free PMC Article
  2. Isolation and characterization of post-splicing lariat-intron complexes. Yoshimoto R, et al. Nucleic Acids Res, 2009 Feb. PMID 19103666, Free PMC Article
  3. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. Paine CT, et al. J Biol Chem, 2000 Jul 21. PMID 10806191
  4. Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism. Herrmann G, et al. Nucleic Acids Res, 2007. PMID 17389648, Free PMC Article
  5. Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans. Ji Q, et al. Exp Cell Res, 2007 Apr 15. PMID 17289020

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U2-type post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type post-mRNA release spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type post-mRNA release spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tuftelin-interacting protein 11
Names
STIP-1
septin and tuftelin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008291.1 → NP_001008292.1  tuftelin-interacting protein 11

    See identical proteins and their annotated locations for NP_001008292.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085809
    UniProtKB/Swiss-Prot
    Q5U2Y6
    UniProtKB/TrEMBL
    A0A8I6A3N9, A6J264
    Related
    ENSRNOP00000000828.3, ENSRNOT00000000828.6
    Conserved Domains (3) summary
    pfam01585
    Location:149 → 193
    G-patch; G-patch domain
    pfam07842
    Location:397 → 666
    GCFC; GC-rich sequence DNA-binding factor-like protein
    pfam12457
    Location:18 → 104
    TIP_N; Tuftelin interacting protein N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    49960025..49972257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271216.1 → XP_063127286.1  tuftelin-interacting protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2Y6
    UniProtKB/TrEMBL
    A6J264
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Y6.1 GenPept UniProtKB/Swiss-Prot:Q5U2Y6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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