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Tesc tescalcin [ Rattus norvegicus (Norway rat) ]

Gene ID: 288689, updated on 2-Nov-2024

Summary

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Official Symbol
Tescprovided by RGD
Official Full Name
tescalcinprovided by RGD
Primary source
RGD:1566317
See related
EnsemblRapid:ENSRNOG00000001128 AllianceGenome:RGD:1566317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566317
Summary
Predicted to enable metal ion binding activity; phosphatase inhibitor activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of macromolecule biosynthetic process; positive regulation of myeloid cell differentiation; and positive regulation of sodium:proton antiporter activity. Predicted to be located in several cellular components, including lamellipodium; nucleoplasm; and ruffle. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human TESC (tescalcin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 1395.4), Brain (RPKM 203.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Tesc in Genome Data Viewer
Location:
12q16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44182741..44216574, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38521832..38555665, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44141258..44174701, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene harakiri, BCL2 interacting protein Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene F-box protein 21 Neighboring gene uncharacterized LOC120095990 Neighboring gene nitric oxide synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Ukarapong S, et al. Exp Cell Res, 2012 Mar 10. PMID 22285131
  2. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. Levay K, et al. Exp Cell Res, 2010 Apr 15. PMID 20060826, Free PMC Article
  3. Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. Zaun HC, et al. J Biol Chem, 2008 May 2. PMID 18321853, Free PMC Article
  4. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Gutierrez-Ford C, et al. Biochemistry, 2003 Dec 16. PMID 14661968
  5. Controlled release systems containing solid dispersions: strategies and mechanisms. Tran PH, et al. Pharm Res, 2011 Oct. PMID 21553168

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of granulocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of megakaryocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcineurin B homologous protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398612.1 → NP_001385541.1  calcineurin B homologous protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    Related
    ENSRNOP00000099700.1, ENSRNOT00000148974.1
    Conserved Domains (1) summary
    COG5126
    Location:20 → 142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    44182741..44216574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249426.4 → XP_006249488.1  calcineurin B homologous protein 3 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:148 → 223
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:147 → 175
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_039090180.1 → XP_038946108.1  calcineurin B homologous protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AI44
    Related
    ENSRNOP00000001490.6, ENSRNOT00000001490.8
    Conserved Domains (1) summary
    COG5126
    Location:10 → 132
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_039090179.1 → XP_038946107.1  calcineurin B homologous protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AI44
    Related
    ENSRNOP00000088101.2, ENSRNOT00000114089.2
    Conserved Domains (2) summary
    COG5126
    Location:103 → 165
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13499
    Location:135 → 215
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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