Cct6a chaperonin containing TCP1 subunit 6A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cct6aprovided by RGD
Official Full Name: chaperonin containing TCP1 subunit 6Aprovided by RGD
Primary source: RGD:1304763
See related: EnsemblRapid:ENSRNOG00000000923 AllianceGenome:RGD:1304763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable WD40-repeat domain binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in several cellular components, including acrosomal vesicle; cell body; and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT6A (chaperonin containing TCP1 subunit 6A). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 226.2), Kidney (RPKM 224.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32508842..32519072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26872736..26883125, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30491584..30501813, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138649 (e-PCR)
- UniSTS:220736

RH134402 (e-PCR)
- UniSTS:217684

Cct6a (e-PCR), detects polymorphism
- UniSTS:536565

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables WD40-repeat domain binding	ISO Inferred from Sequence Orthology more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in chaperone mediated protein folding independent of cofactor	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of zona pellucida receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-complex protein 1 subunit zeta

Names: chaperonin containing Tcp1, subunit 6A (zeta 1); chaperonin subunit 6a (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.