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Usp42 ubiquitin specific peptidase 42 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288482, updated on 10-Oct-2024

Summary

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Official Symbol
Usp42provided by RGD
Official Full Name
ubiquitin specific peptidase 42provided by RGD
Primary source
RGD:1305231
See related
EnsemblRapid:ENSRNOG00000001059 AllianceGenome:RGD:1305231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be active in cytosol and nucleus. Orthologous to human USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 69.9), Adrenal (RPKM 69.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp42 in Genome Data Viewer
Location:
12p11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15903110..15954429)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10800864..10840785)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12840131..12878207)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 3 Neighboring gene uncharacterized LOC134481266 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene cytohesin 3 Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene Rac family small GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression of Usp42 during embryogenesis and spermatogenesis in mouse. Kim YK, et al. Gene Expr Patterns, 2007 Jan. PMID 16904385
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 42
Names
deubiquitinating enzyme 42
ubiquitin specific protease 42
ubiquitin thioesterase 42
ubiquitin thiolesterase 42
ubiquitin-specific-processing protease 42
NP_001099379.1
XP_017453778.1
XP_063127209.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105909.1 → NP_001099379.1  ubiquitin carboxyl-terminal hydrolase 42

    See identical proteins and their annotated locations for NP_001099379.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474012
    UniProtKB/Swiss-Prot
    D3ZU96
    UniProtKB/TrEMBL
    A0A8L2UH81
    Related
    ENSRNOP00000001404.6, ENSRNOT00000001404.7
    Conserved Domains (2) summary
    cd02661
    Location:109 → 409
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05109
    Location:423 → 776
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15903110..15954429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598289.3 → XP_017453778.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    UniProtKB/Swiss-Prot
    D3ZU96
    UniProtKB/TrEMBL
    A0A8L2UH81
    Conserved Domains (2) summary
    cd02661
    Location:109 → 409
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05109
    Location:423 → 776
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_063271139.1 → XP_063127209.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    UniProtKB/Swiss-Prot
    D3ZU96
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZU96.1 GenPept UniProtKB/Swiss-Prot:D3ZU96

Gene LinkOut

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