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Katnal1 katanin catalytic subunit A1 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288449, updated on 2-Nov-2024

Summary

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Symbol
Katnal1provided by RGD
Full Name
katanin catalytic subunit A1 like 1provided by RGD
Primary source
RGD:1359252
See related
EnsemblRapid:ENSRNOG00000047618 AllianceGenome:RGD:1359252
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; identical protein binding activity; and microtubule severing ATPase activity. Predicted to be involved in microtubule severing. Predicted to act upstream of or within spermatogenesis. Predicted to be located in cytoplasm; microtubule; and spindle pole. Predicted to be part of katanin complex. Predicted to be active in microtubule cytoskeleton. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 70.4), Brain (RPKM 69.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Katnal1 in Genome Data Viewer
Location:
12p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (11130935..11192330)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (6094663..6156114)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (7495436..7550205)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554603 Neighboring gene uncharacterized LOC134481258 Neighboring gene ribosomal protein L35A, pseudogene 8 Neighboring gene uncharacterized LOC102554734 Neighboring gene uncharacterized LOC102553253 Neighboring gene uncharacterized LOC108352416 Neighboring gene uncharacterized LOC134478827

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility. Smith LB, et al. PLoS Genet, 2012. PMID 22654668, Free PMC Article
  2. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, et al. Mol Cell Proteomics, 2016 May. PMID 26929214, Free PMC Article
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule severing ATPase activity ISO
Inferred from Sequence Orthology
more info
  
enables microtubule severing ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in microtubule severing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule severing ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule severing ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule severing ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of katanin complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
katanin p60 ATPase-containing subunit A-like 1
Names
katanin p60 ATPase-containing subunit A-like 1-like
katanin p60 subunit A-like 1
p60 katanin-like 1
NP_001006957.1
XP_006248878.1
XP_006248879.1
XP_017453970.1
XP_017453971.1
XP_038945085.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006956.1 → NP_001006957.1  katanin p60 ATPase-containing subunit A-like 1

    See identical proteins and their annotated locations for NP_001006957.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083673
    UniProtKB/Swiss-Prot
    Q5XIK7
    UniProtKB/TrEMBL
    A6K183
    Related
    ENSRNOP00000068753.1, ENSRNOT00000077328.3
    Conserved Domains (3) summary
    pfam09336
    Location:448 → 486
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:400 → 444
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:207 → 376
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    11130935..11192330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248817.5 → XP_006248879.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006248879.1

    UniProtKB/Swiss-Prot
    Q5XIK7
    UniProtKB/TrEMBL
    A6K183
    Conserved Domains (3) summary
    pfam09336
    Location:448 → 486
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:400 → 444
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:207 → 376
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

  2. XM_017598482.3 → XP_017453971.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIK7
    UniProtKB/TrEMBL
    A6K183
    Conserved Domains (3) summary
    pfam09336
    Location:448 → 486
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:400 → 444
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:207 → 376
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

  3. XM_017598481.3 → XP_017453970.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIK7
    UniProtKB/TrEMBL
    A6K183
    Conserved Domains (3) summary
    pfam09336
    Location:448 → 486
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:400 → 444
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:207 → 376
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

  4. XM_006248816.5 → XP_006248878.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006248878.1

    UniProtKB/Swiss-Prot
    Q5XIK7
    UniProtKB/TrEMBL
    A6K183
    Conserved Domains (3) summary
    pfam09336
    Location:448 → 486
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:400 → 444
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:207 → 376
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

  5. XM_039089157.2 → XP_038945085.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    Conserved Domains (3) summary
    pfam09336
    Location:282 → 320
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:234 → 278
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:41 → 210
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIK7.1 GenPept UniProtKB/Swiss-Prot:Q5XIK7

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