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NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 [ Bos taurus (domestic cattle) ]

Gene ID: 288380, updated on 12-Oct-2024

Summary

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Official Symbol
NDUFS1provided by VGNC
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S1provided by VGNC
Primary source
VGNC:VGNC:56131
See related
BGD:BT20795; Ensembl:ENSBTAG00000021976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NDUFS1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (94459779..94489927, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene translation initiation factor IF-2 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene small nucleolar RNA SNORD51 Neighboring gene small nucleolar RNA SNORA41 Neighboring gene eukaryotic translation elongation factor 1 beta 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors. Shinzawa-Itoh K, et al. Biochemistry, 2010 Jan 26. PMID 19961238
  2. Mitochondrial NADH:ubiquinone reductase: complementary DNA sequence of the import precursor of the bovine 75-kDa subunit. Runswick MJ, et al. Biochemistry, 1989 Nov 28. PMID 2514801
  3. Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I). Ohnishi ST, et al. Biochim Biophys Acta, 2010 Dec. PMID 20599678, Free PMC Article
  4. New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals. Ohnishi ST, et al. Biochim Biophys Acta, 2010 Dec. PMID 20513438
  5. Architecture of mammalian respiratory complex I. Vinothkumar KR, et al. Nature, 2014 Nov 6. PMID 25209663, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.
    Title: New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals.
  2. Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I).
    Title: Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).
  3. Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors
    Title: Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC140590

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Names
CI-75kD
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
complex I-75kD
NP_777245.1
XP_005202770.1
XP_024854963.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174820.4 → NP_777245.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_777245.1

    Status: PROVISIONAL

    Source sequence(s)
    BC120069
    UniProtKB/Swiss-Prot
    P15690, Q0VCP7
    UniProtKB/TrEMBL
    A0AAA9TSL9
    Related
    ENSBTAP00000029301.3, ENSBTAT00000029301.4
    Conserved Domains (1) summary
    cl26508
    Location:31 → 722
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    94459779..94489927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202713.5 → XP_005202770.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005202770.1

    UniProtKB/Swiss-Prot
    P15690, Q0VCP7
    UniProtKB/TrEMBL
    A0AAA9TSL9
    Conserved Domains (1) summary
    cl26508
    Location:31 → 722
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

  2. XM_024999195.2 → XP_024854963.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P15690, Q0VCP7
    UniProtKB/TrEMBL
    A0AAA9TSL9
    Conserved Domains (1) summary
    cl26508
    Location:31 → 722
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15690.1 GenPept UniProtKB/Swiss-Prot:P15690

Gene LinkOut

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