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Sidt1 SID1 transmembrane family, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288109, updated on 2-Nov-2024

Summary

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Official Symbol
Sidt1provided by RGD
Official Full Name
SID1 transmembrane family, member 1provided by RGD
Primary source
RGD:1559616
See related
EnsemblRapid:ENSRNOG00000002013 AllianceGenome:RGD:1559616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA transmembrane transporter activity; cholesterol binding activity; and double-stranded RNA binding activity. Predicted to be involved in RNA transport. Predicted to be located in membrane. Predicted to be active in lysosome and plasma membrane. Orthologous to human SIDT1 (SID1 transmembrane family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 65.0), Thymus (RPKM 18.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sidt1 in Genome Data Viewer
Location:
11q21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69867758..69965377)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56362788..56459939)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61320480..61416560)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC134481069 Neighboring gene spindle and centriole associated protein 1 Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel family of mammalian transmembrane proteins involved in cholesterol transport. Méndez-Acevedo KM, et al. Sci Rep, 2017 Aug 7. PMID 28785058, Free PMC Article
  2. Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. Li W, et al. J Biol Chem, 2015 Jul 31. PMID 26067272, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding IEA
Inferred from Electronic Annotation
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SID1 transmembrane family member 1
Names
Msid2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100653.1 → NP_001094123.1  SID1 transmembrane family member 1 precursor

    See identical proteins and their annotated locations for NP_001094123.1

    Status: VALIDATED

    Source sequence(s)
    AY562215, BE112870, JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q6Q3F5
    UniProtKB/TrEMBL
    D4A117
    Conserved Domains (1) summary
    pfam13965
    Location:187 → 810
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    69867758..69965377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597923.3 → XP_017453412.1  SID1 transmembrane family member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A153, D4A117
    Related
    ENSRNOP00000112686.1, ENSRNOT00000131276.1

  2. XM_006248328.5 → XP_006248390.1  SID1 transmembrane family member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADX2, D4A117
    Related
    ENSRNOP00000085335.2, ENSRNOT00000098261.2
    Conserved Domains (1) summary
    pfam13965
    Location:187 → 806
    SID-1_RNA_chan; dsRNA-gated channel SID-1

  3. XM_039088181.2 → XP_038944109.1  SID1 transmembrane family member 1 isoform X3

    UniProtKB/TrEMBL
    D4A117
    Related
    ENSRNOP00000092423.2, ENSRNOT00000095341.2
    Conserved Domains (1) summary
    pfam13965
    Location:184 → 787
    SID-1_RNA_chan; dsRNA-gated channel SID-1

  4. XM_063270390.1 → XP_063126460.1  SID1 transmembrane family member 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q3F5.2 GenPept UniProtKB/Swiss-Prot:Q6Q3F5

Gene LinkOut

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