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Alg3 ALG3, alpha-1,3- mannosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 287983, updated on 2-Nov-2024

Summary

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Official Symbol
Alg3provided by RGD
Official Full Name
ALG3, alpha-1,3- mannosyltransferaseprovided by RGD
Primary source
RGD:1306004
See related
EnsemblRapid:ENSRNOG00000001712 AllianceGenome:RGD:1306004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 44.0), Adrenal (RPKM 43.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alg3 in Genome Data Viewer
Location:
11q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93804859..93810403)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80300487..80306014)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83985484..83991706)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene uncharacterized LOC102551647 Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. Körner C, et al. EMBO J, 1999 Dec 1. PMID 10581255, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Names
alpha-1,3-mannosyltransferase ALG3
asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)
asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog
dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
NP_001135835.1
XP_006248620.1
XP_063126400.1
XP_063126401.1
XP_063126402.1
XP_063126403.1
XP_063126404.1
XP_063126405.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142363.1 → NP_001135835.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

    Status: VALIDATED

    Source sequence(s)
    BC088475, CO401508, FM075565
    UniProtKB/TrEMBL
    A6JSA4
    Conserved Domains (1) summary
    pfam05208
    Location:49 → 406
    ALG3; ALG3 protein

RNA

  1. NR_024535.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC088475, FM075565

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93804859..93810403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270332.1 → XP_063126402.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X4

    UniProtKB/TrEMBL
    Q5M7T0

  2. XM_063270333.1 → XP_063126403.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X5

    UniProtKB/TrEMBL
    A0A8I6GKZ1

  3. XM_006248558.4 → XP_006248620.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X2

    UniProtKB/TrEMBL
    M0R7D2
    Related
    ENSRNOP00000095000.2, ENSRNOT00000119074.2
    Conserved Domains (1) summary
    pfam05208
    Location:49 → 309
    ALG3; ALG3 protein

  4. XM_063270330.1 → XP_063126400.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X1

    Related
    ENSRNOP00000002331.8, ENSRNOT00000002331.10

  5. XM_063270331.1 → XP_063126401.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X3

  6. XM_063270334.1 → XP_063126404.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X6

  7. XM_063270335.1 → XP_063126405.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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