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Yars2 tyrosyl-tRNA synthetase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287924, updated on 28-Oct-2024

Summary

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Official Symbol
Yars2provided by RGD
Official Full Name
tyrosyl-tRNA synthetase 2provided by RGD
Primary source
RGD:1311696
See related
AllianceGenome:RGD:1311696
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CGI-04; RGD1311696
Summary
Predicted to enable several functions, including L-tyrosine binding activity; protein homodimerization activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix and nuclear body. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 56.6), Adrenal (RPKM 56.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Yars2 in Genome Data Viewer
Location:
11q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98136530..98142320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (84632350..84638138, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88882615..88888377, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene dynamin 1-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene U4 spliceosomal RNA Neighboring gene plakophilin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome. Riley LG, et al. Am J Hum Genet, 2010 Jul 9. PMID 20598274, Free PMC Article
  2. Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features. Bonnefond L, et al. Structure, 2007 Nov. PMID 17997975
  3. Human mitochondrial TyrRS disobeys the tyrosine identity rules. Bonnefond L, et al. RNA, 2005 May. PMID 15840810, Free PMC Article
  4. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Bonnefond L, et al. Biochemistry, 2005 Mar 29. PMID 15779907
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables L-tyrosine binding IEA
Inferred from Electronic Annotation
more info
  
enables L-tyrosine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial tyrosyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine--tRNA ligase, mitochondrial
Names
tyrRS
tyrosyl-tRNA synthetase 2 (mitochondrial)
tyrosyl-tRNA synthetase, mitochondrial
NP_001009627.1
XP_038943984.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009627.1 → NP_001009627.1  tyrosine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_001009627.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088224
    UniProtKB/Swiss-Prot
    Q5I0L3
    UniProtKB/TrEMBL
    A6JSQ9
    Conserved Domains (2) summary
    cd00805
    Location:68 → 350
    TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
    PRK05912
    Location:37 → 468
    PRK05912; tyrosyl-tRNA synthetase; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    98136530..98142320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088056.2 → XP_038943984.1  tyrosine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05912
    Location:44 → 317
    PRK05912; tyrosyl-tRNA synthetase; Validated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0L3.1 GenPept UniProtKB/Swiss-Prot:Q5I0L3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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