St6galnac1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St6galnac1provided by RGD
Official Full Name: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by RGD
Primary source: RGD:1562048
See related: EnsemblRapid:ENSRNOG00000000251 AllianceGenome:RGD:1562048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Siat7A
Summary: Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in host-mediated regulation of intestinal microbiota composition; oligosaccharide biosynthetic process; and protein glycosylation. Predicted to be active in Golgi membrane. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10q32.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102471481..102481876, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101972656..101983053, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105713305..105723700, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1alpha-TAK1 signalling pathway.
Title: Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1α-TAK1 signalling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of symbiont process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Names: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6 GalNAc alpha-2,6-sialyltransferase 1; ST6GALNAC1, alpha-2,6-sialyltransferase 1; alpha-2,6-sialyltransferase ST6GalNAc I; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A

NP_001099329.1

EC 2.4.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105859.1 → NP_001099329.1 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 precursor

See identical proteins and their annotated locations for NP_001099329.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HKY7, G3V9C4, Q6ZYN7

Related

ENSRNOP00000042177.3, ENSRNOT00000042321.7

Conserved Domains (1) summary

pfam00777
Location:232 → 518

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)