U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd300lf Cd300 molecule-like family member F [ Rattus norvegicus (Norway rat) ]

Gene ID: 287818, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cd300lfprovided by RGD
Official Full Name
Cd300 molecule-like family member Fprovided by RGD
Primary source
RGD:1309733
See related
EnsemblRapid:ENSRNOG00000021424 AllianceGenome:RGD:1309733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CLM-1; CD300f; RGD1309733
Summary
Predicted to enable several functions, including interleukin-4 receptor binding activity; phosphatidylserine binding activity; and virus receptor activity. Predicted to be involved in several processes, including interleukin-13-mediated signaling pathway; regulation of apoptotic cell clearance; and regulation of innate immune response. Predicted to act upstream of or within osteoclast differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human CD300LF (CD300 molecule like family member f). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 27.8), Spleen (RPKM 22.8) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cd300lf in Genome Data Viewer
Location:
10q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100858924..100875111, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100359942..100376130, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103669781..103690584, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693477 Neighboring gene transfer RNA alanine (anticodon AGC) 73 Neighboring gene RAB37, member RAS oncogene family Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
  
enables ceramide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-4 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response-activating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-13-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-13-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-4-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CMRF35-like molecule 1
Names
CD300 antigen-like family member F

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025111.2 → NP_001020282.1  CMRF35-like molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001020282.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q566E6
    UniProtKB/TrEMBL
    D0VBM0
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:203 → 298
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. NM_001394215.1 → NP_001381144.1  CMRF35-like molecule 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D0V9T5, D0VBM0
    Conserved Domains (2) summary
    pfam15330
    Location:188 → 267
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
    cd05716
    Location:24 → 125
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    100858924..100875111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768338.3 → XP_008766560.1  CMRF35-like molecule 1 isoform X3

    UniProtKB/TrEMBL
    D0VBM0
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:188 → 295
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. XM_008768337.3 → XP_008766559.1  CMRF35-like molecule 1 isoform X2

    UniProtKB/TrEMBL
    D0VBM0
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:203 → 310
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  3. XM_017597155.2 → XP_017452644.1  CMRF35-like molecule 1 isoform X1

    UniProtKB/TrEMBL
    D0VBM0
    Related
    ENSRNOP00000033887.7, ENSRNOT00000039284.7
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:210 → 317
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  4. XM_008768340.4 → XP_008766562.1  CMRF35-like molecule 1 isoform X6

    UniProtKB/TrEMBL
    D0VBM0
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:169 → 276
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  5. XM_063268777.1 → XP_063124847.1  CMRF35-like molecule 1 isoform X5

    UniProtKB/TrEMBL
    A0A0H2UHU2

  6. XM_008768339.4 → XP_008766561.1  CMRF35-like molecule 1 isoform X4

    UniProtKB/TrEMBL
    D0VBM0
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:210 → 289
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  7. XM_008768342.4 → XP_008766564.1  CMRF35-like molecule 1 isoform X7

    UniProtKB/TrEMBL
    D0VBM0, F1M5J1
    Conserved Domains (3) summary
    cd05716
    Location:28 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 126
    IG_like; Immunoglobulin like
    pfam15330
    Location:169 → 248
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  8. XM_039085667.2 → XP_038941595.1  CMRF35-like molecule 1 isoform X8

    Conserved Domains (1) summary
    pfam15330
    Location:42 → 149
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  9. XM_063268778.1 → XP_063124848.1  CMRF35-like molecule 1 isoform X9

RNA

  1. XR_005489765.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q566E6.1 GenPept UniProtKB/Swiss-Prot:Q566E6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools