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Rpa1 replication protein A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287524, updated on 2-Nov-2024

Summary

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Official Symbol
Rpa1provided by RGD
Official Full Name
replication protein A1provided by RGD
Primary source
RGD:1307376
See related
EnsemblRapid:ENSRNOG00000003123 AllianceGenome:RGD:1307376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cb1-727
Summary
Enables single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process; meiotic cell cycle; and protein localization to site of double-strand break. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; in utero embryonic development; and positive regulation of cell population proliferation. Part of DNA replication factor A complex. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 385.9), Heart (RPKM 209.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpa1 in Genome Data Viewer
Location:
10q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60647185..60698279, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60148869..60199970, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62140419..62191518, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene uncharacterized LOC120095264 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene F-box protein 5, pseudogene 1 Neighboring gene ribosomal protein L37, pseudogene 4 Neighboring gene SET and MYND domain containing 4 Neighboring gene serpin family F member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Replication protein A is the major single-stranded DNA binding protein detected in mammalian cell extracts by gel retardation assays and UV cross-linking of long and short single-stranded DNA molecules. Seroussi E, et al. J Biol Chem, 1993 Apr 5. PMID 8463251
  2. Human replication protein A unfolds telomeric G-quadruplexes. Salas TR, et al. Nucleic Acids Res, 2006. PMID 16973897, Free PMC Article
  3. Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. Haring SJ, et al. J Biol Chem, 2008 Jul 4. PMID 18469000, Free PMC Article
  4. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Wang Y, et al. Nat Genet, 2005 Jul. PMID 15965476
  5. Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Safa L, et al. Biochimie, 2014 Aug. PMID 24747047

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication IC
Inferred by Curator
more info
 PubMed 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in lateral element ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
replication protein A 70 kDa DNA-binding subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394069.1 → NP_001380998.1  replication protein A 70 kDa DNA-binding subunit

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2KAT3
    Related
    ENSRNOP00000078632.1, ENSRNOT00000116502.2
    Conserved Domains (1) summary
    TIGR00617
    Location:2 → 612
    rpa1; replication factor-a protein 1 (rpa1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60647185..60698279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767961.4 → XP_008766183.1  replication protein A 70 kDa DNA-binding subunit isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAT3
    Conserved Domains (3) summary
    cd04474
    Location:82 → 184
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    pfam08646
    Location:357 → 502
    Rep_fac-A_C; Replication factor-A C terminal domain
    pfam16900
    Location:201 → 285
    REPA_OB_2; Replication protein A OB domain

  2. XM_063268676.1 → XP_063124746.1  replication protein A 70 kDa DNA-binding subunit isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047843.1: Suppressed sequence

    Description
    NM_001047843.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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